5-Lipoxygenase-Inhibitors from Medicinal Plants

Wagner, H.; Fessler, Beate; Geyer, Bettina; Daily, Anna E.

doi:10.1055/s-2007-969356

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“…This agrees with our findings that wedelolactone (8) (IC50: 2.5 piM), isolated by us from Eclipta alba and Wedelia calendulacea, has nearly the same inhibitory activity as the most potent lipoxygenase inhibitor so far reported, i.e. nordihydroguaretic acid (NDGA; IC50: 1.5 liNt) (32). Chemiluminescence due to oxygen radicals is inhibited in a concentration-dependent manner by wedelolactone in the concentration range 3 x 10 to 3 x i0 .tM.…”

Section: Lipophific Substituents Enhance the Inhibitory Propertiessupporting

confidence: 92%

“…Chemiluminescence due to oxygen radicals is inhibited in a concentration-dependent manner by wedelolactone in the concentration range 3 x 10 to 3 x i0 .tM. Since similar inhibitory behaviour is displayed by NDGA, the radical scavenger properties of this class of compound appear to be confirmed (32). Investigations of the structure-activity relationships of the coumestan series, however, show that strong inhibitory properties are displayed only by derivatives with catechol-type substitution in ring B and an OHgroup or OH-group together with a second lipophilic group (OCH3, 0C2H5) in ring A (33).…”

Section: Lipophific Substituents Enhance the Inhibitory Propertiesmentioning

confidence: 71%

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Search for New Plant Constituents with Potential Antiphlogistic and Antiallergic Activity

Wagner¹

1989

Planta Med

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Structure-activity relationships obtained from in vitro screening results obviously indicate that the highest inhibition effects on cyclooxygenase and 5-lipoxygenase are found amongst the class of phenolic compounds (flavonoids, polyphenols, coumestans, phenol carboxylic acids) and arachidonic acid analogous (alkylamides, retinoids, arylheptanoids, thiosulfinates, sulfinyl disulfides). The antiinflammatory activities of some triterpenenic acids, sesquiterpene lactones, and polysaccharides may be due to their immunomodulating activities on the complement and/or T-lymphocyte populations, respectively. In the search for potential antiallergic and antiasthmatic compounds, the thiosulfinates of onion were found to be active principles of the drug. The mechanism of action of some other antiallergic plant drugs (i.e. Tylophora asthmatica, Adhatoda vasica, etc.) has not yet been clarified.

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Section: Lipophific Substituents Enhance the Inhibitory Propertiessupporting

confidence: 92%

Section: Lipophific Substituents Enhance the Inhibitory Propertiesmentioning

confidence: 71%

Search for New Plant Constituents with Potential Antiphlogistic and Antiallergic Activity

Wagner¹

1989

Planta Med

Self Cite

View full text Add to dashboard Cite

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5-Lipoxygenase-Inhibitors from Medicinal Plants

Cited by 1 publication

References 0 publications

Search for New Plant Constituents with Potential Antiphlogistic and Antiallergic Activity

Search for New Plant Constituents with Potential Antiphlogistic and Antiallergic Activity

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