5-Methoxy-1-(3,4,5-trimethoxyphenyl)-1H-indole

Abstract

The title compound, C18H19NO4, was prepared as an indole derivative with possible anti­mitotic properties. The planes of the indole and trimethoxy­phenyl rings make a dihedral angle of 45.35 (5)° with one another. In the crystal, mol­ecules related by a twofold screw axis exhibit arene C—H⋯arene-π inter­actions which are 3.035 (1) Å in length.

Medicinal and pesticidal potentials of the constituents of the essential oil from Adenia cissampeloides leaves

“…One of such compounds, 5-methoxy-1-(3,4,5-trimethylphenyl)-1-H-indole, is described as having possible anti-mitotic properties. 51 Aromatic ethers derived from indole have been synthesized and found useful for the treatment of diseases linked to the dysfunction of 5HT1-like receptors. 52 5-hydroxytryptamine (5HT), commonly called serotonin, is proposed to play an important role in various pathological conditions, such as psychiatric disorders, including anxiety, depression, aggressiveness, panic attacks, obsessive compulsive disorders, schizophrenia, suicidal tendency, and some neurodegenerative disorders, including Alzheimer's disease, Parkinsonism, as well as other health disorders, such as migraine, cephalalgia and those linked to alcoholism.…”