5-p-Alkoxyphenyl- and 5-(p-alkoxyphenyl)-5-methylhydantoins

Azaryan, L. V.; Avetisyan, S. A.; Akopyan, N. E.; Dzhagatspanyan, I. A.; Chaushyan, K. A.; Mndzhoyan, O. L.

doi:10.1007/bf00778057

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2023

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“…The affinity of the investigated compounds towards certain types of intermolecular interactions was analysed through molecular properties represented by the aromaticity descriptors and through reactivity profiling. As 5-phenylhydantoins exhibit versatile biological effects, 15 their binding modes in the active site of neuronal voltage gated sodium channels, matrix metalloproteinase 12 and aldose reductase were rationalized through molecular docking analysis. Understanding chiral recognition in crystals of the investigated compounds and recognition mechanisms underlying their biological activity may provide a molecular basis for the design of effective drugs, in which enantiomers can be separated by crystallization.…”

Section: Introductionmentioning

confidence: 99%