5-(Perylen-3-ylethynyl)uracil Derivatives Inhibit Reproduction of Respiratory Viruses

Abstract

In this work, we describe the synthesis of 5-(perylen-3-ylethynyl)uridine and its ability to effectively inhibit the replication of respiratory disease pathogens in cell culture, namely: influenza A virus (IVA); type 3 parainfluenza virus (PIV-3); and human respiratory syncytial virus (RSV). Related known compounds were also analyzed: 5-(perylen-3-ylethynyl)-2′-deoxy-uridine; 5-(perylen-3-ylethynyl)-arabino-uridine; and 1-carboxymethyl-3-pivaloyloxymethyl-5-(perylen-3-ylethynyl)uracil.

Antiviral activity of singlet oxygen-photogenerating perylene compounds against SARS-CoV-2: Interaction with the viral envelope and photodynamic virion inactivation

“…Perylene derivatives are synthetic amphipathic structures with broad-spectrum antiviral activity against multiple enveloped and phylogenetically unrelated viral pathogens, including influenza A virus ( Orthomyxoviridae ), human parainfluenza virus type 3 ( Paramyxoviridae ), vesicular stomatitis virus (VSV, Rhabdoviridae ), hepatitis C virus (HCV, Flaviviridae ) ( Colpitts et al., 2013 ), human respiratory syncytial virus (RSV, Paramyxoviridae ) ( Nikolayeva et al., 2020 ), tick-borne encephalitis virus (TBEV, Flaviviridae ) ( Orlov et al., 2016 ), African swine fever virus ( Asfarviridae ) ( Hakobyan et al., 2018 ), and herpes simplex viruses (HSV-1, HSV-2, Herpesviridae ) ( Colpitts et al., 2013 ; Speerstra et al., 2018 ). Recently, they have also been demonstrated to be active against yellow fewer virus and SARS-CoV-2 ( Chistov et al., 2023 ).…”

Recent Efforts in Identification of Privileged Scaffolds as Antiviral Agents

“…All the compounds had comparable EC 50 values that varied from 0.5 to 7.1 μM, which led to strong selectivity index (SI) values. All the examined compounds had SI values higher than the threshold of 10, which permits, despite high CC 50 values, to consider a preparation promising for further research, as in the case of compound cm1pUY11 [44] …”

“…All the examined compounds had SI values higher than the threshold of 10, which permits, despite high CC 50 values, to consider a preparation promising for further research, as in the case of compound cm1pUY11. [44] According to Goktas inhibitors, further investigation against a wider variety of influenza A viruses (including more recent A/H3 N2 strains) identified compounds 59 and 60 (Figure 24) with promising antiviral activity. [45] A natural substance with widespread antiviral entry activity called oleanolic acid (OA) and three more analogs, echinocystic acid (EA), ursolic acid (UA), and betulinic acid, were conjugated with sialic acid by Xu Han et al In the MDCK cell culture, the antiviral activity against the influenza A/WSN/33 (H1 N1) virus was tested on a total of twenty-four conjugated sialic acid and penta cyclic triterpene derivatives with various linkers.…”

Phenoxazine nucleoside derivatives with a multiple activity against RNA and DNA viruses

“…The assay was performed as described before [ 27 ]. In brief, a series of 3-fold dilutions were prepared from DMSO solution of the compound (2 mg/mL), added to MDCK cell monolayer and incubated for 1 h in CO 2 -incubator at 37 °C.…”