5 Reversible Mri Features and Knee Pain Fluctuation: The Most Study

Zhang, Y.; Nevitt, M.C.; Niu, Jingwen; Lewis, C.E.; Torner, J.; Guermazi, Ali; Roemer, Frank W.; McCulloch, Charles E.; Felson, David T.

doi:10.1016/s1063-4584(07)61641-0

Cited by 10 publications

(5 citation statements)

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“…This longitudinal study suggested that a diminution in synovitis would reduce pain. The findings of Hill and colleagues have been corroborated by Zhang and colleagues [ 24 ], who used data from serial MRIs in the MOST study and found that change in synovitis score was strongly related to change in pain – a decrease in score being associated with a lower pain score. The presence of a knee effusion and its size are also correlated with the occurrence of pain in the knee, and change in effusion size relates directly (bigger effusion, more pain) to change in pain [ 22 ].…”

Section: The Relation Of Pain To Structural Pathology In Osteoarthritmentioning

confidence: 73%

Developments in the clinical understanding of osteoarthritis

2009

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With the recognition that osteoarthritis is a disease of the whole joint, attention has focused increasingly on features in the joint environment which cause ongoing joint damage and are likely sources of pain. This article reviews current ways of assessing osteoarthritis progression and what factors potentiate it, structural abnormalities that probably produce pain, new understandings of the genetics of osteoarthritis, and evaluations of new and old treatments.

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Section: The Relation Of Pain To Structural Pathology In Osteoarthritmentioning

confidence: 73%

Developments in the clinical understanding of osteoarthritis

2009

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“…Importantly, fluctuations in psychological factors reflecting mental well-being are associated with fluctuations in pain severity 25. Additionally, some of the OA-related pathology itself can change or fluctuate over time, which in turn alters the nociceptive input and therefore the pain experience 26. Finally, developing more persistent pain over time may be a reflection of the development of central sensitization 27…”

Section: Discussionmentioning

confidence: 99%

Consistency of knee pain: correlates and association with function

Neogi

Nevitt

Yang

et al. 2010

Osteoarthritis and Cartilage

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Objective The extent and factors associated with knee pain fluctuation are not well-known. We evaluated the prevalence, correlates, and association with function of consistency of knee pain. Design Participants of The Multicenter Osteoarthritis (MOST) Study, a cohort of individuals with or at high risk of knee osteoarthritis (OA) had baseline knee x-rays, questionnaires, and a question about frequent knee pain (FKnP) (pain on most of the past 30 days) at two time points: a telephone screen and a later clinic visit. We computed the prevalence of inconsistent knee pain (positive answer to FKnP question at only one time point) and consistent knee pain (positive answer to FKnP question at both time points). We evaluated the association of consistency of FKnP with a number of sociodemographic factors, pain severity, and function. Results There were 2940 participants with complete data (5867 knees) (mean age 62, mean BMI 30.7, 60% female). Of those, 2977 knees had pain, with 43% having inconsistent and 57% having consistent knee pain. Those with radiographic OA (OR 0.46), depressive symptoms (OR 0.73), and widespread pain (OR 0.68) (all p<0.05) were less likely to have inconsistent compared with consistent knee pain. Pain, function, and strength were significantly better in persons with 2 knees that had inconsistent compared with consistent pain. Conclusions A substantial proportion of persons with knee pain have inconsistent knee pain, associated with better physical function and strength (adjusting for pain severity). Such pain may be suggestive of an earlier stage of disease.

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“…Similarly, Magnetic Resonance Imaging (MRI) may be useful to assess the morphology, composition and structure of the articular cartilage in OA 6,7 . Indeed, progress in MRI and MRI analysis technologies offers certain promise to enhance our understanding of OA pathobiology, and the relationship between structural changes and clinical outcomes such as pain 8,9 . Nevertheless, further standardization and clinical validation of such MRI approaches through large scale studies are still required for them to become widely established as clinical tools 10,11 .…”

Section: Introductionmentioning

confidence: 99%