5‐Substituted 1,2,4‐Triazole‐3‐Carboxylates and 5‐Substituted Ribavirin Analogs Synthesis

Abstract

Ribavirin analogs substituted at position 5 of the heterocyclic base are interesting for their biological activity. This protocol describes a synthetic route to several such ribavirin analogs with a wide range of substituents.© 2021 Wiley Periodicals LLC. Basic Protocol 1: Synthesis and purification of 5‐substituted ethyl 1,2,4‐triazole‐3‐carboxylates – synthetic precursors of nucleobases Basic Protocol 2: Synthesis and purification of protected 1,2,4‐triazole nucleoside analogs Basic Protocol 3: Synthesis and purification of 5‐substituted ribavirin analogs