In today’s dynamic work environment, teams are increasingly confronted with disruptions. While there are different types of disruptions that teams face, we contend that team composition disruptions that occur during the completion of a team’s task can be especially challenging. We also argue that it is important to consider different types of team composition changes as they create different demands for team adaptation. Specifically, we assess the effects of loss of a team member and change in team membership resulting from injury substitution. We examine how these two types of team composition disruptions impact coordination and team outcomes (i.e., goals scored) by leveraging data from 2,280 soccer games in the English Premier League. We found that team member loss impaired both team coordination and outcomes while team member substitution only impacted team coordination. Moreover, we build upon and extend existing research that has examined team familiarity by distinguishing between familiarity that is built amongst members on the current team (i.e., current team familiarity) and familiarity that has developed as a result of members working together in prior teams (i.e., prior team familiarity). This distinction appears important as we did not find evidence of a main effect of prior team familiarity on coordination but found evidence of a reversing curvilinear effect of current team familiarity on coordination. Finally, the indirect effect of team member loss on team outcomes through team coordination was more pronounced when teams had low (compared to high) prior team familiarity.