503 Detection of significant coronary artery stenosis by resting wall motion abnormalities, in patients with suspected coronary artery disease

Craciunescu, I.; Şerban, Marinela; Sârbu, Vasile; Deleanu, Dan; Ghiorghiu, Ioana; Mihăescu, Christine; Aron-Niculescu, I.G.; Ginghină, Carmen

doi:10.1016/s1525-2167(06)60293-x

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Echo measures of the mitral valve annulus (MVA), pulmonary valve annulus (PVA), and main pulmonary artery (MPA) were also obtained (Figure 1). Ao diameters were measured from leading edge to leading edge in the parasternal long axis in end diastole, as previously described (Roman et al, 1989; Lang et al, 2006). By 2-dimensional imaging the MPA segment and the PVA were measured in the parasternal short axis view.…”

Section: Methodsmentioning

confidence: 99%

Aorta Measurements are Heritable and Influenced by Bicuspid Aortic Valve

Martin¹,

Hinton²,

Zhang³

et al. 2011

Front. Gene.

View full text Add to dashboard Cite

Objectives: To determine whether the contributions of genetics and bicuspid aortic valve (BAV) independently influence aortic (Ao) dimensions. Background: Ao dilation is a risk factor for aneurysm, dissection, and sudden cardiac death. Frequent association of BAV with Ao dilation implicates a common underlying defect possibly due to genetic factors. Methods: Families enriched for BAV underwent standardized transthoracic echocardiography. In addition to BAV status, echocardiographic measures of Ao (annulus to descending Ao), pulmonary artery, and mitral valve annulus (MVA) diameters were obtained. Using variance components analysis, heritability was estimated with and without BAV status. Additionally, bivariate genetic analyses between Ao dimensions and BAV were performed. Results: Our cohort was obtained from 209 families enriched for BAV. After adjusting for age, body surface area, and sex, individuals with BAV had a statistically significant increase in all echocardiographic measurements (p < 0.006) except descending Ao and MVA. Individuals with BAV were at greater odds of having Ao dilation (OR = 4.44, 95% CI 2.93–6.72) than family members without BAV. All echocardiographic measurements exhibited moderate to strong heritability (0.25–0.53), and these estimates were not influenced by inclusion of BAV as a covariate. Bivariate genetic analyses supported that the genetic correlation between BAV and echo measures were not significantly different from zero. Conclusion: We show for the first time that echocardiographic measurements of Ao, pulmonary artery and MVA diameters are quantitative traits that exhibit significant heritability. In addition, our results suggest the presence of BAV independently influences the proximal Ao and pulmonary artery measures but not those in the descending Ao or MVA.

show abstract

Section: Methodsmentioning

confidence: 99%