SciVee 2012
DOI: 10.4016/41020.01
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5040 Sympathizing Intraocular Pressure Response to Contralateral Steroid Drop Usage

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Cited by 2 publications
(2 citation statements)
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“…Results from a recent 4-years clinical trial at 75 sites on intravitreal triamcinolone have reported a mean 34-52 days from time of injection to IOP increases larger than 10 mmHg, 57 which coincides quite well with the result in sheep. In addition, and consistent with what it has been reported for prednisolone administrations on the sheep, 44 and with a chart’s review study on steroid treated patients, 58 we did not observe any steroid effect in the contralateral eye using durezol. Altogether, these findings plus logistics associated with the experimental procedure, including daily maintenance costs, place the sheep durezol model as the preferable translational model for steroid-induced gene therapy experiments.…”
Section: Discussionsupporting
confidence: 92%
“…Results from a recent 4-years clinical trial at 75 sites on intravitreal triamcinolone have reported a mean 34-52 days from time of injection to IOP increases larger than 10 mmHg, 57 which coincides quite well with the result in sheep. In addition, and consistent with what it has been reported for prednisolone administrations on the sheep, 44 and with a chart’s review study on steroid treated patients, 58 we did not observe any steroid effect in the contralateral eye using durezol. Altogether, these findings plus logistics associated with the experimental procedure, including daily maintenance costs, place the sheep durezol model as the preferable translational model for steroid-induced gene therapy experiments.…”
Section: Discussionsupporting
confidence: 92%
“…This result is contrary to a previous study that showed that topical steroid eye drops did not have a significant effect on the IOP of the contralateral eye. [15] The results of our study suggest that pediatric patients are more vulnerable to elevated IOP caused by a systemic effect from topical steroids. Therefore, the IOP of the fellow eye should be monitored during the use of topical steroid eye drops on the operated eyes of pediatric patients.…”
Section: Discussionmentioning
confidence: 80%