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Abstract

We compared clinical feature, risk factors, B-MRI patterns, and laboratory findings between patients with the cryptogenic (cancer-related stroke) and conventional stroke mechanism (CSM). Results: Over the study period, a total of 88 cancer patients underwent B-MRI scanning for suspicion of IS. 43 (49%) patients had a final diagnosis of IS. 27 (63%) patients had the cryptogenic mechanism and 16 (37%) patients had the CSM. The levels of D-dimer were higher in the cryptogenic group (median level of 10.00 [3.77-17.72] µg/dL) than CSM group (median level of 2.60 (1.50-3.74) µg/dL). The area under the curve for prediction of cryptogenic mechanism was 0.802 (95% CI, 0.652-0.908) for D-dimer. In multivariate analysis, D-dimer levels of > 3.9 µg/dL (adjusted OR 27.453; 95% CI, 1.382-545.322) and the diffusion-weighted imaging (DWI) lesion pattern of multiple vascular territories (adjusted OR 37.610; 95% CI, were significantly associated with the cryptogenic group in critically ill cancer patients. Conclusions: The levels of D-dimer and the DWI lesion pattern may be helpful to evaluate precise mechanism and treat IS in critically ill cancer patients.