515 Role of Bone Marrow-Derived Cells in Experimental Chronic Pancreatitis

Marrache, Frédéric; Pendyala, Swaroop; Bhagat, Govind; Betz, Kelly S.; Song, Zhigang; Wang, Yichen

doi:10.1016/s0016-5085(08)60339-x

Cited by 20 publications

References 34 publications

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Biology of pancreatic stellate cells—more than just pancreatic cancer

Ferdek

Jakubowska

2017

Pflugers Arch - Eur J Physiol

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Pancreatic stellate cells, normally quiescent, are capable of remarkable transition into their activated myofibroblast-like phenotype. It is now commonly accepted that these cells play a pivotal role in the desmoplastic reaction present in severe pancreatic disorders. In recent years, enormous scientific effort has been devoted to understanding their roles in pancreatic cancer, which continues to remain one of the most deadly diseases. Therefore, it is not surprising that considerably less attention has been given to studying physiological functions of pancreatic stellate cells. Here, we review recent advances not only in the field of pancreatic stellate cell pathophysiology but also emphasise their roles in physiological processes.

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Biology of pancreatic stellate cells—more than just pancreatic cancer

Ferdek

Jakubowska

2017

Pflugers Arch - Eur J Physiol

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Molecular mechanisms of pancreatic myofibroblast activation in chronic pancreatitis and pancreatic ductal adenocarcinoma

et al. 2021

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Novel and Experimental Therapies in Chronic Pancreatitis

Jagannath

Garg

2017

Dig Dis Sci

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Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas. The currently available treatment of CP is aimed at controlling symptoms and managing complications. Unfortunately, no specific treatment is available to halt the progression of the disease process because the pathophysiological perturbations in CP are not well understood. In this review, we discuss various therapeutic targets and investigational agents acting on these targets. Among these, therapies modulating immune cells and those acting on pancreatic stellate cells appear promising and may translate into clinical benefit in near future. However, these experimental therapies are mostly in animal models and they do not recapitulate all aspects of human disease. Still they may be beneficial in developing effective therapeutic modalities to curb inflammation in chronic pancreatitis.

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515 Role of Bone Marrow-Derived Cells in Experimental Chronic Pancreatitis

Cited by 20 publications

References 34 publications

Biology of pancreatic stellate cells—more than just pancreatic cancer

Biology of pancreatic stellate cells—more than just pancreatic cancer

Molecular mechanisms of pancreatic myofibroblast activation in chronic pancreatitis and pancreatic ductal adenocarcinoma

Novel and Experimental Therapies in Chronic Pancreatitis

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