522

Abstract

PEDS without progression to SZ occurred in 7 patients with onset 23 (range 11-44) hours post ROSC, and 74 patients (81%) had no SZ or PEDS. Seizures and PEDS were generalized in all patients. 80% of SZ patients were treated with benzodiazepines, fosphenytoin, levetiracetam, or valproic acid beginning 10 (3-20) hours after onset, and controlled in 25% of treated patients. GO occurred in 38% of the total cohort, 65% who met HACA criteria, but 0% of SZ and 14% of PEDS patients. Conclusions: Epileptiform activity occurred in 18.7% and SZ in 10% of TH patients after cardiac arrest, with onset delayed nearly 24 hours. All activity was generalized, and detectable with simplified frontotemporal EEG monitoring. Anti-epileptic medications were started late. Although SZ were controlled in 25% of those treated, no patient with SZ or PEDS made a good recovery.