528 Comparative Clinical Studies of Mianserin and Carbamazepine Effecacy for Pain and Itch Management in Patients With End‐renal Disease Under Chronic Hemodialysis

Psychotropic Drugs for the Management of Chronic Pain and Itch

“…It was shown that carbamazepine and oxcarbazepine at clinically relevant concentrations potentiate the GABAAR [91]. At the same time, according to our data, carbamazepine, imipramine and trazodone are effective in management of neuropathic pain and itching syndromes [15,20,21,22].…”

“…However, there were mismatches, too. Our own clinical studies at First Pavlov State Medical University have identified antipruritic and/or analgesic efficacy of the following compounds (Figure 2): tianeptine (atypical tricyclic antidepressant), citalopram (selective serotonin reuptake inhibitors (SSRI)), mianserin (tetracyclic antidepressant), carbamazepine (anticonvulsant), trazodone (serotonin antagonist and reuptake inhibitor (SARI)), chlorprothixene (antipsychotic) [9,20,21,22]. Mianserin, carbamazepine and tianeptine contain the V-like group in their 3D-structure (Figure 2), but they are not NMDAR blockers in clinically relevant concentration [23].…”

“…Before the medical treatment pains were localised in upper and lower extremities, vertebral region, and coxal bones; durations of pain paroxysm were from 2−3 h to 20 h per a day; the average pain intensity in the group was 4.98 ± 2.37 (VAS); SCORAD index was 18.0 ± 7.5. After carbamazepine treatment, the respective indexes were: VAS—1.64 ± 0.88; SCORAD index—5.1 ± 2.0 [20,21].…”