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Rotsch, Terry D.; Spanton, Meredith; Cugier, Phyllis; Plasz, Andrew C.

doi:10.1023/a:1015844705331

Cited by 12 publications

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Antibiotics, Pharmaceutical Analysis of

Gilpin

Pachla³

2000

Encyclopedia of Analytical Chemistry

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An antibiotic is a chemical substance, produced by microorganisms (or recently, synthetic routes) which has the capacity to inhibit the growth of other microorganisms/bacterial agents. The terminology for antibiotics stems from the Latin term of antibiosis and the noun antibiotic was coined by Professor Waksman in 1942. Considered as a single therapeutic class, antibiotics are one of the most diverse groups of medicinal agents. They can be grouped into several subclasses depending on their source, structure and activity. These are the cephalosporins, penicillins, quinolones, streptomyces and tetracycline. In addition to these agents, the sulfonamides and other miscellaneous compounds are also included owing to their antibacterial activity.

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Antibiotics, Pharmaceutical Analysis of

Gilpin

Pachla³

2000

Encyclopedia of Analytical Chemistry

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Cleaning Verification for Highly Potent Compounds

Pack

2008

Formulation and Analytical Development for Low‐Dose Oral Drug Products

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Preparation of prolonged release clarithromycin microparticles for oral use and theirin vitro evaluation

2006

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Prolonged release microparticles of clarithromycin (CL) were prepared using Eudragit RL 100 and RS 100 by spray-drying and casting-drying techniques. For the characterization of those microparticles, preparation yield, particle size distribution, X-ray diffraction, thermal behavior, active agent content and in vitro dissolution from the microparticles were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. All the formulations obtained showed prolonged release when compared to pure clarithromycin. Microparticles prepared by spray-drying method had a slower release compared to those of casting-drying method. Spray-drying method seems to be a more suitable method to prepare microparticles for prolongation in release.

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Cited by 12 publications

References 1 publication

Antibiotics, Pharmaceutical Analysis of

Antibiotics, Pharmaceutical Analysis of

Cleaning Verification for Highly Potent Compounds

Preparation of prolonged release clarithromycin microparticles for oral use and theirin vitro evaluation

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