As multitiered systems of support (MTSS) for improving student emotional/behavioral (EB) functioning are being scaled up nationally (Horner et al., 2014), there is a critical need to define how these approaches meet the needs of students presenting internalizing EB problems such as depression, anxiety, and trauma-related concerns. Contributing to the improvement of MTSS is the systematic joining of positive behavioral interventions and supports (PBIS) and school mental health (SMH) services. A recently defined interconnected systems framework (ISF; Barrett, Eber, & Weist, 2013) provides explicit guidance on doing this work, and a national workgroup for ISF is exploring its implementation in sites around the country. The theme of improving prevention and intervention for youth with internalizing issues is a significant emphasis in this effort. However, many schools and collaborating partners from the mental health and other youth-serving systems struggle to develop multitiered programs for youth with internalizing challenges. The underlying tenets and approaches for addressing internalizing problem behavior differ from those that focus on improving more distinct externalizing behaviors such as noncompliance, disruptiveness, rule violation, aggression, attention problems, and acting out. The overall goal of this article is to build from important prior reviews (e.g., McIntosh, Ty, & Miller, 2014) and lessons being learned as the ISF is implemented in sites across the country to improve multitiered promotion/prevention, early intervention, and intervention for students presenting internalizing problems. Within MTSS efforts, school staff and community collaborators (as in the ISF) continue to struggle to implement programs for youth with internalizing problems. Objectives of this article are to review background factors limiting attention to internalizing issues within MTSS and to present recommendations for moving the field forward in improving practice, research, and policy on these issues, with particular attention paid to the ISF and its critical role in this agenda. There are three sections to the article.