533 Chronic Administration of Chondroitin Sulfate Does Not Affect Cytochrome P450 and Nadph P450 Reductase in the Rabbit

Montell, E.; Iovu, M-O.; Héroux, Lucie; Vergés, J.; Souich, Patrick du

doi:10.1016/s1063-4584(08)60572-5

Cited by 2 publications

(1 citation statement)

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“…However, CS prevented the increase of NF-kB nuclear translocation and in nitric oxide hepatic concentrations triggered by a turpentine-induced inflammatory [54]. These results confirm in vivo that CS prevents NF-κB activation induced by an inflammatory reaction in tissues other than the articulation.…”

Section: Human Use Of Chondroitin Sulphatesupporting

confidence: 55%

Immunomodulatory and anti‐inflammatory effects of chondroitin sulphate

Souich

Garcı́a

Vergés

et al. 2009

J Cellular Molecular Medi

174

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Chondroitin sulphate (CS) is a natural glycosaminoglycan present in the extracellular matrix and is formed by the 1–3 linkage of D-glucuronic acid to N-acetylgalactosamine. In chondrocytes, CS diminishes interleukin-1 p (IL-1p)-induced increases in p38 mitogen-activated protein kinase (p38MAPK) and signal-regulated kinase 1/2 (Erk1/2) phosphorylation, and decreases nuclear factor-KB (NF-kB) nuclear translocation and as a consequence, reduces the formation of pro-inflammatory cytokines, IL-1 p and TNF-a, and pro-inflammatory enzymes, such as phospholipase A2 (PLA2), cyclooxygenase 2 (COX-2) and nitric oxide synthase-2 (NOS-2). The mechanism of action of CS explains its beneficial effect on the cartilage, synovial membrane and subchondral bone. On the other hand, in vivo, CS given orally prevents hepatic NF-κB nuclear translocation, suggesting that systemic CS may elicit an anti-inflammatory effect in many tissues besides the articulation. There is preliminary evidence showing that in human beings, CS may be of benefit in other diseases where inflammation is an essential marker, such as psoriasis and atherosclerosis. The review of the literature suggest that CS might also be of interest for the treatment of other diseases with an inflammatory and/or autoimmune character, such as inflammatory bowel disease, degenerative diseases of the central nervous system and stroke, multiple sclerosis and other autoimmune diseases.

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Section: Human Use Of Chondroitin Sulphatesupporting

confidence: 55%

Immunomodulatory and anti‐inflammatory effects of chondroitin sulphate

Souich

Garcı́a

Vergés

et al. 2009

J Cellular Molecular Medi

174

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Alflutop - in modern symptom - modifying osteoarthritis therapy

Дроздов

Ших

Serebrova

et al. 2019

Terapevticheskii arkhiv

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One of the serious problems during the treatment of osteoarthritis (OA) is the developing of adverse drug events during therapy. Nonsteroidal anti - inflammatory drugs (NSAIDs) are the first drugs with the high incidence and severity of adverse events. This article describes OA treatment strategies approaches for OA are presented using the complex drug Alflutop, which has a composition similar to the human hyaline cartilage. The drug has anti - inflammatory and analgesic effects, normalizes the function of the affected joints, improves the quality of patients’ life, also has a structure - modifying effect. Such therapy is safe, well tolerable for patients, and can be used used as a starting complex OA treatment.

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533 Chronic Administration of Chondroitin Sulfate Does Not Affect Cytochrome P450 and Nadph P450 Reductase in the Rabbit

Cited by 2 publications

References 0 publications

Immunomodulatory and anti‐inflammatory effects of chondroitin sulphate

Immunomodulatory and anti‐inflammatory effects of chondroitin sulphate

Alflutop - in modern symptom - modifying osteoarthritis therapy

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