536 Characterization of gene expression profile in Kupffer cells stimulated with IFN alpha and gamma

Myeloid STAT3 Inhibits T Cell-Mediated Hepatitis by Regulating T Helper 1 Cytokine and Interleukin-17 Production

“…These findings suggest that both IL-17 and IFN-γ participate to T-cell-mediated hepatitis, and that IL-17 plays a mild role as compared to the major contribution of IFN-γ. The essential role of IFN-γ in T-cell hepatitis is probably attributed to multiple detrimental functions of IFN-γ in the liver, including IFN-γ induction of hepatocyte apoptosis and cell cycle arrest,21 IFN-γ induction of expression of chemokines and their receptors on liver cells,34 and IFN-γ activation of Kupffer cells/macrophages 43. Although IL-17 also targets multiple cell types in the liver to induce expression of inflammatory cytokines and chemokines44 (Fig.…”

Pathological Alteration in the Choroid Plexus of Alzheimer’s Disease: Implication for New Therapy Approaches

“…Excessive generation of NO has been implicated in the pathogenesis of AD (Smith et al, 1997; Aliyev et al, 2004), and plays an important role in Aβ-induced mitochondrial dysfunction (Keil et al, 2004). The interaction between NO and cytochrome c oxidase controls mitochondrial production of hydrogen peroxide, which has been shown to be implicated in cellular redox signaling (Galli et al, 2003; Carreras et al, 2004). These results, together with previous findings (Veereshwarayya et al, 2006; Petrosillo et al, 2007), support the hypothesis that Aβ interferes with oxidative phosphorylation, which results in oxidative stress, and demonstrate that reactive oxygen species (ROS) generation is secondary to mitochondrial damage.…”

Elevated Interferon Gamma Signaling Contributes to Impaired Regeneration in the Aged Liver

“…Microarray gene expression data set comparing the transcriptional profiles of young and aged livers at 0.5, 1, 2, 4, 24, 38, and 48 hour after resection surgery was generated previously in our laboratory. To determine whether the IFNregulated genes are differentially overexpressed in the aged livers after resection surgery, we selected two sets of genes from published studies exhibiting a greater than fourfold increase in response to IFN-g (26,27) and compared the differential expression profile between young and old livers in our array data set at time points 0, 0.5, 1, 2, and 4 hour after PH ( Figure 2A). The aged livers showed a general upregulation of the chosen genes compared with young livers with statistically significant higher expression (sign test; p value < .05) at time points 0.5, 1, 2, and 4 hour in Set A and 0.5 and 2 hour for Set B.…”

“…Changes in the expression profile of IFN-g responsive genes in young and old animals at early time points after partial hepatectomy. (A) Expression fold change between aged and young livers at time points 0, 0.5, 1, 2, and 4 hours after partial hepatectomy in genes previously shown to exhibit elevated expression in response to IFN-g treatment in published studies-Set A (26); Set B(27). *Denotes p < .05 (significance value for directional change-Sign test).…”