54 K Spin Transition Temperature Shift in a Fe₆L₄ Octahedral Cage Induced by Optimal Fitted Multiple Guests

Abstract

Spin-crossover (SCO) coordination cages are at the forefront of research for their potential in crafting next-generation molecular devices. However, due to the scarcity of SCO hosts and their own limited cavities, the interplay between the SCO host and the multiple guests binding has remained elusive. In this contribution, we present a family of pseudo-octahedral coordination cages (M 6 L 4 , M = Zn II , Co II , Fe II , and Ni II ) assembled from a tritopic tridentate ligand L with metal ions. The utilization of Fe II ion leads to the successful creation of the Fe 6 L 4 -type SCO cage. Host−guest studies of these M 6 L 4 cages reveal their capacity to encapsulate four adamantine-based guests. Notably, the spin transition temperature T 1/2 of Fe 6 L 4 is dependent on the multiple guests encapsulated. The inclusion of adamantine yields an unprecedented T 1/2 shift of 54 K, a record shift in guest-mediated SCO coordination cages to date. This drastic shift is ascribed to the synergistic effect of multiple guests coupled with their optimal fit within the host. Through a straightforward thermodynamic cycle, the binding affinities of the high-spin (HS) and low-spin (LS) states are separated from their apparent binding constant. This result indicates that the LS state has a stronger binding affinity for the multiple guests than the HS state. Exploring the SCO thermodynamics of host−guest complexes allows us to examine the optimal fit of multiple guests to the host cavity. This study reveals that the T 1/2 of the SCO host can be manipulated by the encapsulation of multiple guests, and the SCO cage is an ideal candidate for determining the multiple guest fit.

Mechanically Interlocked Water-Soluble Pd6 Host for the Selective Separation of Coal Tar-Based Planar Aromatic Molecules

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Proton-Induced Reversible Spin-State Switching in Octanuclear FeIII Spin-Crossover Metal–Organic Cages

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“…Intriguingly, the nature of the guest can also influence the SCO properties of the cage host. , Pioneering work by Nitschke et al has led to the development of self-assembled tetrahedral SCO-MOCs capable of encapsulating guests that stabilize distinct spin states to varying degrees . In a notable advancement, Sun and colleagues demonstrated an [Fe 6 II (ligand) 4 ]-type SCO-MOCs, where the spin-transition temperature ( T 1/2 ) of the host cage shifted by 54 K upon encapsulating multiple adamantane guests …”