547 Obesity as a risk factor for prostate cancer: a role for adipocytokines and involvement of tyrosine kinase pathway

Hoda, M. Raschid; Galayda, D.; Fischer, Katrin; Wagner, Samuel; Heynemann, H.; Fornara, P

doi:10.1016/s1359-6349(10)71348-3

Cited by 2 publications

(2 citation statements)

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“…On the contrary, the adipocytokine signaling pathway is a fully connected graph. More interestingly, adipocytokines such as leptin and adiponectin are important signaling molecules involved in neuronal circuits for food intake and are related to obesity, insulin resistance and cancer [39][40][41][42][43][44].…”

Section: Expanding Candidate Genes By Protein-protein Interactions Anmentioning

confidence: 99%

EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder

Zhao

2013

Sci. China Life Sci.

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Eating disorder is a group of physiological and psychological disorders affecting approximately 1% of the female population worldwide. Although the genetic epidemiology of eating disorder is becoming increasingly clear with accumulated studies, the underlying molecular mechanisms are still unclear. Recently, integration of various high-throughput data expanded the range of candidate genes and started to generate hypotheses for understanding potential pathogenesis in complex diseases. This article presents EDdb (Eating Disorder database), the first evidence-based gene resource for eating disorder. Fifty-nine experimentally validated genes from the literature in relation to eating disorder were collected as the core dataset. Another four datasets with 2824 candidate genes across 601 genome regions were expanded based on the core dataset using different criteria (e.g., protein-protein interactions, shared cytobands, and related complex diseases). Based on human protein-protein interaction data, we reconstructed a potential molecular sub-network related to eating disorder. Furthermore, with an integrative pathway enrichment analysis of genes in EDdb, we identified an extended adipocytokine signaling pathway in eating disorder. Three genes in EDdb (ADIPO (adiponectin), TNF (tumor necrosis factor) and NR3C1 (nuclear receptor subfamily 3, group C, member 1)) link the KEGG (Kyoto Encyclopedia of Genes and Genomes) "adipocytokine signaling pathway" with the BioCarta "visceral fat deposits and the metabolic syndrome" pathway to form a joint pathway. In total, the joint pathway contains 43 genes, among which 39 genes are related to eating disorder. As the first comprehensive gene resource for eating disorder, EDdb (http://eddb.cbi.pku.edu.cn) enables the exploration of gene-disease relationships and cross-talk mechanisms between related disorders. Through pathway statistical studies, we revealed that abnormal body weight caused by eating disorder and obesity may both be related to dysregulation of the novel joint pathway of adipocytokine signaling. In addition, this joint pathway may be the common pathway for body weight regulation in complex human diseases related to unhealthy lifestyle. eating disorder, database, adipocytokine signaling pathway, pathway analysis Citation:Zhao M, Li X M, Qu H. EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder.

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Section: Expanding Candidate Genes By Protein-protein Interactions Anmentioning

confidence: 99%

EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder

Zhao

2013

Sci. China Life Sci.

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“…Most of the studies indicate that in obese persons, leptin might potentiate the growth of cancer cells, and adiponectin appears to have an opposite effect (Housa et al, 2006). A recent in vitro study suggested an association between obesity‐associated hyperleptinemia and an increased risk for CaP, but further investigations are necessary to clarify whether these data have clinical relevance for use as a prognostic marker for predicting CaP risk (Hoda et al, 2010). It has been observed that body composition and leptin are related to the CaP aggressiveness, but not with its prevalence (López Fontana et al, 2011).…”

Section: Obesity Leptin Level and Prostate Healthmentioning

confidence: 99%

Diet, Obesity, and Prostate Health: Are We Missing the Link?

Tewari

Rajender

Natu

et al. 2012

Journal of Andrology

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Prostate problems, such as benign prostatic hyperplasia, prostatic intra-epithelial neoplasia, prostatitis, and prostate cancer have been recognized as problems largely related to androgens and genetic factors. They affect a large fraction of the elderly population, contributing significantly to morbidity and mortality. Estrogen has also now been recognized as one of the important regulators of prostate growth. Diet, general health, and obesity were disregarded as the causative or complicating factors until very recently. Increasing episodes of prostate problems, complications in overweight/obese individuals, or both have attracted attention toward these contemporary risk factors. Prostate problems are reportedly less frequent or less severe in areas in which a plant-based diet is predominant. Consumption of certain fatty acids, particularly of animal origin, has been correlated with increased prostate problems. As adipose tissue is increasingly being regarded as hormonally active tissue, high body fat and obesity need in-depth exploration to understand the associated risk of prostate problems. Adipose tissue is now known to affect circulating levels of several bioactive messengers and therefore could affect the risk of developing prostate problems in addition to several other well-recognized health problems. Nevertheless, increased plasma volume, excess tissue growth, and fat deposition could affect resection and number of biopsies required, thus adding further complications because of a delayed diagnosis. In short, evidence is gathering to support the influence of diet and obesity on prostate health. In this review article, we have tried to make this connection more apparent using supporting published data.

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547 Obesity as a risk factor for prostate cancer: a role for adipocytokines and involvement of tyrosine kinase pathway

Cited by 2 publications

References 0 publications

EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder

EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder

Diet, Obesity, and Prostate Health: Are We Missing the Link?

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