548 Frictional property of cartilage regenerated with a 3-D scaffold-free synthetic tissue (3DST)

Katakai, Daisuke; Imura, Machiko; Ando, Wataru; Tateishi, Kousuke; Yoshikawa, Hideki; Nakamura, Norimasa; Fujie, Hiromichi

doi:10.1299/jsmemecjo.2006.5.0_151

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It appears that this requirement can be better satisfied by in-vitro grown scaffold-neocartilage constructs, in which the artificial template initially provides adequate mechanical support [8,9], than by scaffold-less engineered cartilage replacements [10,11]. The specific structure, mechanical characteristics, and chemical environment of the scaffold can, in principle, also promote cell adhesion, proliferation, and differentiation and thereby guide tissue formation [12] and integration with the surrounding native tissue [13] and the subchondral bone [14].…”

Section: Introductionmentioning

confidence: 99%

Directed cell growth in multi-zonal scaffolds for cartilage tissue engineering

et al. 2016

View full text Add to dashboard Cite

Articular cartilage serves as a low-friction cushion in synovial joints and is vital for mammalian skeletal movements. Due to its avascular nature and the low cell density, the tissue has a limited ability to regenerate, and damage due to injury, wear and tear, or disease usually requires surgical intervention. While articular cartilage had been predicted to be one of the first tissues to be successfully engineered, it proved to be challenging to reproduce the complex architecture and biomechanical properties of the native tissue. Here we report the fabrication of multi-layer polymer nanocomposite scaffolds that mimic the structural design, chemical cues, and mechanical characteristics of mature articular cartilage. These scaffolds guide the morphology, orientation, and phenotypic state of cultured chondrocytes in a spatially controlled manner, support the growth of tissue with features that are reminiscent of the natural analogue, and promote localized hydroxyapatite formation to permit integration with the subchondral bone.

show abstract