2023
DOI: 10.1093/ndt/gfad063c_5599
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#5599 Febuxostat in Combination With Anakinra or Ph Neutralization Improve the Outcomes in Hyperuricemia-Related Uric Acid Crystalluria in Mice

Abstract: Background and Aims Currently, it is unknown whether CKD patients with hyperuricemia (HU)-related uric acid (UA) crystalluria, also known as chronic UA nephropathy, would benefit from targeting HU, UA crystallization, and/or inflammation to slow down the progressive decline of kidney function. Although large multi-center RCTs with xanthine oxidase inhibitors (XOIs) such as allopurinol and two Mendelian randomization studies have disproven a causal link between HU and CKD progression, one cann… Show more

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