572: Levocarnitine Supplementation for Hypertriglyceridemia in Patients Receiving Parenteral Nutrition

Grucz, Traci; Crow, Jessica; Davis, S. Lindsey; Gager, Erin; Beattie, Jessica; Shermock, Kenneth M.; Sugrue, David; Jarrell, Andrew

doi:10.1097/01.ccm.0000728176.64669.a8

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, 55.2% and 71.2% of patients had been prescribed these drugs, respectively. Additionally, IV levocarnitine can moderately decrease TG concentrations in patients receiving PN, but the effect is modest [ 32 ] and its use is not approved in our country for this indication.…”

Section: Discussionmentioning

confidence: 99%

Acute Hypertriglyceridemia in Patients with COVID-19 Receiving Parenteral Nutrition

et al. 2021

View full text Add to dashboard Cite

Hypertriglyceridemia is a metabolic complication associated with parenteral nutrition (PN). It is unknown if patients with acute respiratory distress syndrome (ARDS) secondary to COVID-19 are more at risk. Our aim was to describe the incidence, risk factors and clinical impact of hypertriglyceridemia in critically ill patients with ARDS-COVID-19 receiving PN. We designed a cohort study of patients with ARDS-COVID-19 infection that required admission to critical care units and nutritional support with PN. Individual PN prescriptions for macronutrients and insulin were provided. Lipid emulsion contained fish oil (SMOFlipid® or Lipoplus®). Hypertriglyceridemia was defined as plasma levels above 400 mg/dL. Eighty-seven patients, 66.6% men, 60.1 ± 10.8 years old, BMI 29.1 ± 5.6 kg/m2, 71% of whom received lopinavir/ritonavir, 56% received Propofol and 55% received Tocilizumab were included. The incidence of hypertriglyceridemia was 37 × 100 patient-days with PN. This complication was more frequent in obese patients (OR 3.34; 95% CI, 2.35–4.33) and in those treated with lopinavir/ritonavir (OR 4.98; 95% CI, 3.60–6.29) or Propofol (OR 2.45; 95% CI, 1.55–3.35). Total mortality was 33.3%, similar between the type of lipid emulsion (p = 0.478). On average, patients with hypertriglyceridemia had a longer requirement of PN compared to the group without elevated triglycerides (TG), probably because of their longer survival (p = 0.001). TG higher than 400 mg/dL was not a protective factor for mortality (OR 0.31; 95% CI, 0.01–1.30). In conclusion, the incidence of hypertriglyceridemia was 37 × 100 patient-days with PN. The risk of this complication is associated with obesity and the use of lopinavir/ritonavir or Propofol.

show abstract

Section: Discussionmentioning

confidence: 99%