576: Opioid detoxification during pregnancy to prevent neonatal abstinence syndrome

Abstract

Little is known about its effects on pregnancy. The objective of this study was to evaluate the pregnancy outcomes in women suffering from EDS. STUDY DESIGN: We conducted a population-based, retrospective cohort study using the United States' Health Care Cost and Utilization Project's Nationwide Inpatient Sample to evaluate pregnancy outcomes in women with EDS, compared to those without EDS, delivering between 1999 and 2013. We used unconditional regression analysis, adjusted for maternal age and race, to compare maternal and fetal outcomes among pregnancies in women with and without EDS. RESULTS: Of the total 13,881,592 births in our cohort, 910 deliveries were to women with EDS. Women with EDS were more likely to be Caucasian, earn a higher income, and smoke. Births to women with EDS were more likely to be premature (OR 1.51 (95% CI 1.20-1.89)). Pregnancies complicated by EDS were more likely to be associated with cervical incompetence (OR 3.22 (95% CI 2.04-5.07)), antepartum hemorrhage (OR 1.79 (95% CI 1.20-2.66)) and placenta previa (OR 2.23 (95% CI 1.29-3.86)). Pregnant women with EDS were also more likely to be delivered by cesarean section (OR 1.61 (95% CI 1.41-1.85)), as well as stay longer than 7 days in the hospital (OR 3.10 (95% CI 2.34-4.09)). CONCLUSION: Pregnant women with EDS are at higher risk of antepartum hemorrhage, placenta previa, cervical incompetence and preterm birth, as well as delivering by cesarean section, when compared to women without EDS. These risks should be taken into consideration and cervical surveillance should be considered.