57Co-Hematoporphyrin Accumulation by Experimental Tumors

Anghileri, L. J.; Heidbreder, M; Mathes, Rachel L.

doi:10.1055/s-0038-1624958

Cited by 10 publications

(4 citation statements)

References 5 publications

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“…Localization was subsequently shown in mammary adenocarcinomas and in neoplasma by in vivo single‐photon emission computed tomography imaging in tumour bearing rats. Hematoporphyrin labelled with 57 Co and 64 Cu coordinated in the tetrapyrrole core, was shown to lack significant tumour localization, however, whilst labelling with 109 Pd was shown to accumulate in murine tumour models, poor tumour visualization in human models was later seen by the authors . Similarly with 111 In, whilst the labelled species localized in murine breast tumours, substantial liver and spleen retention was again observed .…”

Section: Hematoporphyrin Labellingmentioning

confidence: 97%

Radiolabelled porphyrins in nuclear medicine

Waghorn

2013

Labelled Comp Radiopharmac

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Amongst tumour-specific substances, hematoporphyrin and synthetic porphyrin derivatives have been widely investigated to identify and delineate neoplastic and malignant tissue. Whilst the tumour localization exhibited by selected porphyrin species has been exploited through photodynamic therapy, several examples of porphyrin derivatives with varied peripheral functionality have been radiolabelled with the aim of developing porphyrin-based nuclear imaging and therapeutic agents. In this review, we look at the approaches and advances in the preparation and uses of such radiolabelled agents for imaging and therapy.

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Section: Hematoporphyrin Labellingmentioning

confidence: 97%

Radiolabelled porphyrins in nuclear medicine

Waghorn

2013

Labelled Comp Radiopharmac

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“…More recently, polylysine has been found to exhibit a large number of unique membrane properties. These include the ability to enhance the cellular uptake of macromolecules (9), to inhibit iodide uptake by thyroid slices (10), to produce pathogenesis of the glomerular epithelium (11), to act as an anticholinesterase (12), to specifically agglutinate the lymphocytes from cancer patients (13), and to either increase or decrease the transport of specific radioisotopes into cells (14). These effects are probably associated with the polycationic character of polylysine and are probably due to specific interactions on the cell membrane.…”

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confidence: 99%

Antineoplastic activity of poly(L-lysine) with some ascites tumor cells.

Arnold¹,

Dagan²,

Gutheil³

et al. 1979

Proc. Natl. Acad. Sci. U.S.A.

106

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ABSIRACT We have found that poly(L-lysine) can be a very effective agent in preventing the growth of Ehrlich ascites tumors in mice. When given optimal doses of poly(L-lysine) (Mr 60 X 103) intraperitoneally for 5 consecutive days, beginning on day 1 after inoculation with Ehrlich ascites cells, White Swiss mice show nearly a 100% remission from subsequent tumor growth. Rechallenge of "cured" animals with tumor cells, however, shows no long-term immunological protection. In tissue culture, poly(L-lysine) shows a related potent cytotoxicity with HeLa cells; interestingly, the D isomer has properties strikingly different from those of the L isomer. In addition, there is a strong molecular weight dependence in that the small polylysine (Mr 3 X 103) possess less than 1/20th the cytotoxicity of large polymers (Mr 70 X 103) on a weight basis in both cell culture and animal studies. At the same time, none of these lysine polymers gives any significant increase in life span to BDF1 mice infected with L1210 murine leukemia cells. We have also further explored the mechanism by which the polylysines express their cytotoxicity. These data indicate that lysine polymers show cell specificity in their action and in some cases they may be beneficial as potent antineoplastic agents, particularly when molecular weight is taken into consideration. For more than 25 years, poly(L-lysine) has been known to have unusual biological properties. Early studies showed that it decreased the infectivity of tobacco mosaic virus (1), disturbed thrombin formation in rats (2), blocked the development of bacteriophage (3, 4), protected chicken embryos from animal viruses (5, 6), and possessed antibacterial activity (7). There was also an early report that indicated that polylysine had some activity against murine tumors (8). More recently, polylysine has been found to exhibit a large number of unique membrane properties. These include the ability to enhance the cellular uptake of macromolecules (9), to inhibit iodide uptake by thyroid slices (10), to produce pathogenesis of the glomerular epithelium (11), to act as an anticholinesterase (12), to specifically agglutinate the lymphocytes from cancer patients (13), and to either increase or decrease the transport of specific radioisotopes into cells (14). These effects are probably associated with the polycationic character of polylysine and are probably due to specific interactions on the cell membrane.Recently, we have been examining the ability of polylysine to serve as an efficient drug carrier (15). In doing the controls for these studies, we found that poly(L-lysitie)s of a certain Mr, (60 X 103) could induce 100% remissions in mice inoculated with Ehrlich ascites when the polymer was administered at increased doses. This paper presents results on the antineoplastic activity and toxicity as functions of polymer molecular weight and concentration. Also, we will provide further information into the mechanism accounting for the antineoplastic and cytotoxic activities of polylysine. MATERIALS AND ...

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“…Hamatoporphyrin-Derivat (HpD) photosensibilisiert nach intravenöser Applikation selektiv maligne Tumoren (2,6,15). Aufgrund seiner photoaktiven Eigensehaften zeigte HpD bei Anregung mit Licht der Wellenldnge 405 nm eine Rotfluoreszenz (1,17,22,23) Wir berichten uber den erfoigreichen Einsatz dieser photodynamisehen Therapie bei einem Patienten mit eiacm Spinaliom der Ohrmuschel (Abb.…”

Section: Introductionunclassified

Photodynamische Lasertumortherapie mit Hämatoporphyrin-Derivat (HpD) eines Spinozellulären Karzinomes der Ohrmuschel

Feyh¹,

Goetz

Martín³

et al. 1989

Laryngo-Rhino-Otol

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Haematoporphyrine-derivative (hpd) selectively photosensitises malignant tumours following intravenous application. 48 hours after injection of hpd an integral laser-light application of the tumour and the surrounding normal tissue was performed. We report on the successful administration of this photodynamic therapy in a patient with a spinocellular carcinoma of the auricle. 16 days after therapy the tumour showed a complete response without damage of the also irradiated surrounding normal tissue. Apart from a temporary sensitivity to light no side effects of the therapy were seen.

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57Co-Hematoporphyrin Accumulation by Experimental Tumors

Cited by 10 publications

References 5 publications

Radiolabelled porphyrins in nuclear medicine

Radiolabelled porphyrins in nuclear medicine

Antineoplastic activity of poly(L-lysine) with some ascites tumor cells.

Photodynamische Lasertumortherapie mit Hämatoporphyrin-Derivat (HpD) eines Spinozellulären Karzinomes der Ohrmuschel

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