583: Preemptive Analgesia With Ibuprofen and Acetaminophen in Pediatric Lower Abdominal Surgery

Kashefi, Parviz; Motahareh, Mirdamadi

doi:10.1016/j.rapm.2008.07.343

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…A more recent meta-analysis identified 54 studies directly comparing the analgesic effect of acetaminophen with ibuprofen (3). Of these, eighteen related to pediatric acute pain control: six supported ibuprofen over acetaminophen (4)(5)(6)(7)(8)(9); one supported ibuprofen over acetaminophen on the day of surgery only (10); three suggested ibuprofen over acetaminophen without reaching statistical significance (11)(12)(13); and the remainder found no difference between the two drugs (14)(15)(16)(17)(18)(19)(20)(21). The authors concluded that ibuprofen is at least as effective as, if not more so than, acetaminophen in both adults and children (3).…”

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confidence: 99%

Explaining the acetaminophen–ibuprofen analgesic interaction using a response surface model

Hannam

Anderson

2011

Pediatric Anesthesia

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This drug interaction modeling example is useful to explain combination therapy nuances and impacts on study design. Differences in effect between single drug therapy and combination therapy should be sought at lower doses and beyond the immediate postoperative period. Combination therapy may prolong the duration of analgesia. The maximum effect (E(MAX) ) limits the early additional analgesic gain from combination therapy beyond commonly used doses.

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confidence: 99%

Explaining the acetaminophen–ibuprofen analgesic interaction using a response surface model

Hannam

Anderson

2011

Pediatric Anesthesia

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Paracetamol (Acetaminophen) Use in Infants and Children Was Never Shown to Be Safe for Neurodevelopment: A Systematic Review

Cendejas-Hernandez¹,

Sarafian²,

Lawton³

et al. 2020

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Background: Although widely believed to be safe for use in infants and children when used as directed, increasing evidence indicates that early life exposure to paracetamol (acetaminophen) may cause long-term neurodevelopmental problems. Further, recent studies in animal models demonstrate that cognitive development is exquisitely sensitive to paracetamol exposure during early development. In this study, evidence for the claim that paracetamol is safe was evaluated using a systematic literature search. Methods: Publications on PubMed between 1974 and 2017 that contained the keywords “infant” and either “paracetamol” or “acetaminophen” were considered. Of those initial 3096 papers, 218 were identified that made claims that paracetamol was safe for use with infants or children. Of these, a total of 103 papers were identified as sources of authority for the safety claim, and 36 of those contained actual experiments designed to test safety. Results and Conclusions: The 36 experiments described had a median follow-up time of 24 hours, and none monitored neurodevelopment. Further, no trial considered total exposure to drug since birth, eliminating the possibility that the effects of drug exposure on long-term neurodevelopment could be accurately assessed. On the other hand, abundant and sufficient evidence was found to conclude that paracetamol does not induce acute liver damage in babies or children when used as directed.

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583: Preemptive Analgesia With Ibuprofen and Acetaminophen in Pediatric Lower Abdominal Surgery

Abstract: Background and Aims: Some studies have documented an opioid sparing effect of ketamin and others have not. In this study we evaluate the effect and side effects of oral ketamin on pain and total dose of opioid which is used after operation.

Cited by 2 publications

References 8 publications

Explaining the acetaminophen–ibuprofen analgesic interaction using a response surface model

Explaining the acetaminophen–ibuprofen analgesic interaction using a response surface model

Paracetamol (Acetaminophen) Use in Infants and Children Was Never Shown to Be Safe for Neurodevelopment: A Systematic Review

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