589 Modulation of the Brain-Gut Axis After 4-Week Intervention With a Probiotic Fermented Dairy Product

Tillisch, Kirsten; Labus, Jennifer S.; Ebrat, Bahar; Stains, Jean; Naliboff, Bruce D.; Guyonnet, Denis; Legrain–Raspaud, Sophie; Trotin, Beatrice; Mayer, Emeran A.

doi:10.1016/s0016-5085(12)60435-1

Cited by 12 publications

(5 citation statements)

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“…The fMRI was conducted during an emotional reactivity task (viewing faces displaying a negative emotional reaction vs. viewing shapes). Based on blood flow assessments during the task, the probiotic group showed diminished activity in the mid/posterior insula vs. the control groups [104]. While preliminary, the results suggest that orally administered probiotics can alter brain activity in regions involved in receiving signals from the gut and the ultimate level of subsequent emotional arousal.…”

Section: Introductionmentioning

confidence: 99%

Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III – convergence toward clinical trials

2013

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Rapid scientific and technological advances have allowed for a more detailed understanding of the relevance of intestinal microbiota, and the entire body-wide microbiome, to human health and well-being. Rodent studies have provided suggestive evidence that probiotics (e.g. lactobacillus and bifidobacteria) can influence behavior. More importantly, emerging clinical studies indicate that the administration of beneficial microbes, via supplementation and/or fecal microbial transplant (FMT), can influence end-points related to mood state (glycemic control, oxidative status, uremic toxins), brain function (functional magnetic resonance imaging fMRI), and mental outlook (depression, anxiety). However, despite the advances in the area of gastro-biological psychiatry, it becomes clear that there remains an urgent need to explore the value of beneficial microbes in controlled clinical investigations. With the history explored in this series, it is fair to ask if we are now on the cusp of major clinical breakthroughs, or are we merely in the quicksand of Autointoxication II?

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Section: Introductionmentioning

confidence: 99%

Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III – convergence toward clinical trials

2013

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“…Strikingly, the positive effects of bacteria on mood are not limited to how people perceive their own emotions but also how people perceive emotions on the faces of others. To this end, researchers found that when healthy women with no gastrointestinal (GI) or psychiatric symptoms consumed a nonfermented probiotic drink daily for 4 weeks, they showed decreased reactivity to negative facial expressions on other people’s faces (angry and sad faces) compared with subjects who consumed a placebo (Tillisch et al, 2012). Taken together, these results suggest that bacteria do not influence emotions simply by ameliorating poor health, as all of these human subjects were already healthy.…”

Section: Emotion and Affective Sciencementioning

confidence: 99%

Microbes and the Mind: How Bacteria Shape Affect, Neurological Processes, Cognition, Social Relationships, Development, and Pathology

Smith

Wissel

2019

Perspect Psychol Sci

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Recent data suggest that the human body is not so exclusively human after all. Specifically, humans share their bodies with approximately 10 trillion microorganisms, collectively known as the microbiome. Chief among these microbes are bacteria, and there is a growing consensus that they are critical to virtually all facets of normative functioning. This article reviews the ways in which bacteria shape affect, neurological processes, cognition, social relationships, development, and psychological pathology. To date, the vast majority of research on interactions between microbes and humans has been conducted by scientists outside the field of psychology, despite the fact that psychological scientists are experts in many of the topics being explored. This review aims to orient psychological scientists to the most relevant research and perspectives regarding the microbiome so that we might contribute to the now widespread, interdisciplinary effort to understand the relationship between microbes and the mind.

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“… 17 However, only preliminary data suggest that such mechanisms may also play a role in healthy subjects or those with IBS. 18 …”

Section: Probiotics In Health and Diseasementioning

confidence: 99%

An update on the use and investigation of probiotics in health and disease

Sanders

Guarner

Guerrant

et al. 2013

Gut

439

286

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Probiotics are derived from traditional fermented foods, from beneficial commensals or from the environment. They act through diverse mechanisms affecting the composition or function of the commensal microbiota and by altering host epithelial and immunological responses. Certain probiotic interventions have shown promise in selected clinical conditions where aberrant microbiota have been reported, such as atopic dermatitis, necrotising enterocolitis, pouchitis and possibly irritable bowel syndrome. However, no studies have been conducted that can causally link clinical improvements to probiotic-induced microbiota changes. Whether a disease-prone microbiota pattern can be remodelled to a more robust, resilient and disease-free state by probiotic administration remains a key unanswered question. Progress in this area will be facilitated by: optimising strain, dose and product formulations, including protective commensal species; matching these formulations with selectively responsive subpopulations; and identifying ways to manipulate diet to modify bacterial profiles and metabolism.

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589 Modulation of the Brain-Gut Axis After 4-Week Intervention With a Probiotic Fermented Dairy Product

Cited by 12 publications

References 0 publications

Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III – convergence toward clinical trials

Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III – convergence toward clinical trials

Microbes and the Mind: How Bacteria Shape Affect, Neurological Processes, Cognition, Social Relationships, Development, and Pathology

An update on the use and investigation of probiotics in health and disease

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