59: Does Introduction of a Sepsis Protocol Reduce Time to Antibiotics or Improve Outcomes for Critical Septic Patients? A Before and After Study

McGrath, Meghan E.; Lada, Pamela; Rebholz, Casey M.; Mitchell, Patricia; Donovan, Joanne M.; Bullock, Holly; Feldman, James A.

doi:10.1016/j.annemergmed.2007.06.090

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Implementation Strategies For Early Goaldirected Therapy And1

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2008

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“…There is a critical threshold for total protocol compliance, however. Of the publications (abstracts) that showed no survival benefit, the compliance to bundle elements was less than optimal [41,56,57]. Thus, the effectiveness of EGDT as with any intervention is significantly related to a critical compliance effort.…”

Section: Implementation Strategies For Early Goaldirected Therapy Andmentioning

confidence: 98%

Early goal-directed therapy in severe sepsis and septic shock: a contemporary review of the literature

Rivers

Coba

Whitmill

2008

Current Opinion in Anaesthesiology

155

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Early goal-directed therapy modulates systemic inflammation and results in significant reductions in morbidity, mortality, and healthcare resource consumption. Early goal-directed therapy has been externally validated and is generalizable across multiple healthcare settings. Because of these robust findings, further emphasis should be placed on overcoming logistical, institutional, and professional barriers to implementation which can save the life of one of every six patients presenting with severe sepsis and septic shock.

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Section: Implementation Strategies For Early Goaldirected Therapy Andmentioning

confidence: 98%