595-nm pulsed dye laser combined with fractional CO2 laser reduces hypertrophic scar through down-regulating TGFβ1 and PCNA

Zhang, Jinxia; Zhou, Shuanglin; Xia, Zhikuan; Peng, Zhuoying; Cheng, Xiaoxian; Yang, Xin; Luo, Weimin

doi:10.1007/s10103-020-03240-7

Cited by 12 publications

(18 citation statements)

References 37 publications

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“…A further subgroup analysis was also performed which revealed that patients at the early stage could experience more significant improvement after the treatment of combined therapy. Ablative fractional CO 2 laser technology has been employed for many years; however, it is only in recent years that this technique has been applied to the treatment of hypertrophic scars (3,4,(13)(14)(15)(16)(17)(18)(19). Several case reports firstly reported the effectiveness of ablative fractional CO 2 laser treatment for hypertrophic scars (20,21), then Makboul et al enrolled 40 patients with hypertrophic scars and confirmed ablative fractional CO 2 laser treatment as a feasible management for hypertrophic scarring (22).…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness and safety of fractional micro-plasma radio-frequency treatment combined with ablative fractional carbon dioxide laser treatment for hypertrophic scar: a retrospective study

Li¹,

Wang²,

Wang³

et al. 2021

Ann Palliat Med

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Background: Hypertrophic scars can be caused by various injuries and lead to a decrease in quality of life of those affected. This study was performed retrospectively in our center to investigate the safety and effectiveness of fractional micro-plasma radio-frequency treatment combined with ablative fractional carbon dioxide (CO 2 ) laser treatment in patients with hypertrophic scar.Methods: This was a retrospective study performed in a single center between January 2019 and December 2020. All patients with hypertrophic scars receiving fractional micro-plasma radio-frequency treatment, ablative fractional CO 2 laser treatment, or combined therapy of both were recruited to the study. The participants were then divided into a single therapy group or combined therapy group. The Vancouver scar scale was used to score and subsequently assess the effectiveness of scar treatment and the changes of scar thickness. Some adverse complications were also recorded to evaluate the safety of treatments. A subgroup analysis was then performed to investigate the differences of effectiveness and safety of combined therapy in scar patients at the early stage and late stage.Results: A total of 64 patients with hypertrophic scars were enrolled in this study, including 45 receiving combined treatment, and 19 receiving single treatment. There was no significant difference in demographic data between the two groups. Notably, combined therapy could more effectively reduce the score of Vancouver scar scale (P=0.026) without significantly increasing the incidence of adverse complications.However, no significant difference was observed in scar thickness between the two groups. Moreover, multiple treatments could further increase the effectiveness of combined therapy according to either the score of Vancouver scar scale or the thickness of scars. Subgroup analysis revealed that combined therapy could reduce the score of Vancouver scar scale and scar thickness in patients much more at the early stage than at the late stage (P=0.032 and 0.042, respectively).Conclusions: This study revealed that fractional micro-plasma radio-frequency treatment combined with ablative fractional CO 2 laser treatment could be more effective in improving hypertrophic scars then single therapy. Also, multiple treatments could enhance the effectiveness of combined treatment, and patients should be encouraged to receive treatment as early as possible.

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Section: Discussionmentioning

confidence: 99%

“…Zhang et al found in their rabbit model that artesunate combined with ablative fractional CO 2 laser effectively reduces hypertrophic scarring (14). Ablative fractional CO 2 laser combined with a variety of laser therapy, such as 595-nm pulsed dye laser, can also better increase the effectiveness of the treatment of hypertrophic scars (15).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and safety of fractional micro-plasma radio-frequency treatment combined with ablative fractional carbon dioxide laser treatment for hypertrophic scar: a retrospective study

Li¹,

Wang²,

Wang³

et al. 2021

Ann Palliat Med

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“… 74 Moreover, in a rabbit model, the use of a fractional CO 2 laser with a 595-nm PDL can enhance the shape and histology of hypertrophic scars by reducing TGFβ1 and proliferating cell nuclear antigen (PCNA) protein expression. 75 In addition, another study found that the mRNA expression of MMP1, 2, and 3 as well as chemokines (Chemokine (C-X-C motif) ligand 1, 2, 5, and 6) and interleukins (IL-6, IL-8, and IL-24) was considerably higher in tissue samples obtained three days following fractional Er:YAG laser treatment. 76 In terms of the treatment of IPL, it suppressed levels of IL-6, tumor necrosis factor-alpha (TNF-α), MMPs, and proteolytic enzymes while raising levels of IL-10 and TGF-β in skin cells.…”

Section: Molecular Changes Induced By Photoelectric Therapy For Scarsmentioning

confidence: 99%

Advances in Photoelectric Therapy for the Early Intervention and Treatment of Traumatic Scars

Zhang¹,

Wang²,

Huang³

2023

CCID

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Traumatic scar is a disease that affected approximately tens of millions of patients worldwide. According to the histological and morphological properties of scars, the traumatic scar typically includes superficial scar, atrophic scar, hypertrophic scar, and keloid. Its formation is a natural consequence of wound healing, regardless of whether the wound was caused by trauma or surgery. However, the production of scars has considerable impacts on the physical and mental health of patients, even causing substantial aesthetic and functional impairments. Prevention or early treatment of scars is the most suitable therapeutic method, including surgical and non-surgical procedures; nevertheless, the benefits of non-operative therapies for scars are quite limited, and surgical treatments are always hard to achieve satisfying outcomes. Through the application of innovative technologies such as lasers, intense pulsed light, and radiofrequency, significant progress has been made in the treatment of traumatic scars. This review highlights the current advancements of photoelectric therapy for the prevention and treatment of various traumatic scars, which may throw light on innovative therapeutic options for scar therapies.

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“…The therapeutic challenge often appears because of the age of the patient, special location and large size of the lesion, and the inherent traumatic nature of some methods. A pulsed dye laser (PDL) is based on the selective photothermolysis principle, producing pulses at wavelengths of 585 nm and 595 nm, which are now widely used in the treatment of vascular anomalies 13,14 . The therapeutic effectiveness and safety of PDL in the context of PG have been evaluated in several studies 2,15–19 .…”

Section: Introductionmentioning

confidence: 99%

“…A pulsed dye laser (PDL) is based on the selective photothermolysis principle, producing pulses at wavelengths of 585 nm and 595 nm, which are now widely used in the treatment of vascular anomalies. 13,14 The therapeutic effectiveness and safety of PDL in the context of PG have been evaluated in several studies. 2,[15][16][17][18][19] Here, we aim to evaluate the clinical effectiveness and safety profile of 595 nm PDL for our treatment of PG in a large series of cases.…”

Section: Introductionmentioning

confidence: 99%

Treatment of pyogenic granuloma in children with a 595 nm pulsed dye laser: A retrospective study of 212 patients

Dong

et al. 2022

Lasers Surg Med

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Background: Pyogenic granuloma (PG) is a common vascular neoplasm in children. Data on 595 nm pulsed dye lasers for the treatment of PG in children remain scarce. Objective: To summarize the clinical characteristics and to evaluate the effectiveness and safety of the 595 nm pulsed dye laser for the treatment of PG in children. Study Design: Retrospective case series. Methods: A retrospective study was performed on 212 patients treated for PG with a 595 nm pulsed dye laser. SPSS version 19.0 was used for statistical analysis.Results: Among all 212 patients treated, 208 showed complete resolution of the lesion, and 4 dropped out after one treatment due to bleeding. A single treatment was sufficient in 139 (66.8%) patients, while two or three treatments were sufficient in 69 (33.2%) patients. Male patients responded better than female patients (χ 2 = 7.603, p =0.006). Lesions in the nonorbital region responded better than those in the orbital region (χ 2 = 7.445, p =0.006). The size of the lesion affected the effectiveness, and lesions with smaller diameters (t = −5.776, p <0.01) and heights (t = −10.368, p <0.01) showed better results. Complications and Side Effects: Twelve patients (5.8%) were reported to have local complications and side effects, including edematous erythema, slight bleeding, hyperpigmentation, and hypopigmentation. The edematous erythema and slight bleeding disappeared gradually after several days. The localized pigment changes usually resolved spontaneously and disappeared completely after 6 months. Conclusions: Our experience confirmed the efficacy and safety of the 595 nm pulsed dye laser for the treatment of PG in children.

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595-nm pulsed dye laser combined with fractional CO2 laser reduces hypertrophic scar through down-regulating TGFβ1 and PCNA

Cited by 12 publications

References 37 publications

Effectiveness and safety of fractional micro-plasma radio-frequency treatment combined with ablative fractional carbon dioxide laser treatment for hypertrophic scar: a retrospective study

Effectiveness and safety of fractional micro-plasma radio-frequency treatment combined with ablative fractional carbon dioxide laser treatment for hypertrophic scar: a retrospective study

Advances in Photoelectric Therapy for the Early Intervention and Treatment of Traumatic Scars

Treatment of pyogenic granuloma in children with a 595 nm pulsed dye laser: A retrospective study of 212 patients

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