5HT in Migraine Patients with Medication-Induced Headache

Hering, R.; Glover, Vivette; Pattichis, K.; Catarci, Teresa; Steiner, TJ

doi:10.1046/j.1468-2982.1993.1306410.x

Cited by 51 publications

(50 citation statements)

References 13 publications

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“…Relja Neurological Clinic, Ospedale Maggiore, Trieste, Italy S22 et al [2], in 1993, reported a reduction in whole blood 5HT in patients with analgesic rebound headache which was normalized on discontinuing the analgesics. This rise in 5HT level in the whole blood paralleled the improvement in headache frequency.…”

mentioning

confidence: 99%

Relevance of analgesic abuse in the maintenance of chronic headaches

Pini¹,

Relja

2000

J Headache Pain

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mentioning

confidence: 99%

Relevance of analgesic abuse in the maintenance of chronic headaches

Pini¹,

Relja

2000

J Headache Pain

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“…This concept is supported by the observation that 1-month withdrawal of drugs involved in analgesic-induced headache results in an increase in blood serotonin levels accompanying the reduction in headache frequency [51].…”

Section: Cdh and Drug Abusementioning

confidence: 90%

Chronic daily headache: biochemical and neurotransmitter abnormalities

et al. 2000

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“…Hering et al 24 observed an increase in blood level of serotonin after withdrawal of overused SM in chronic daily headache patients. In addition, these authors analyzed the platelet membrane transduction of patients with daily headache suggesting that the overuse of SM would result in a modification of this process, possibly playing a role in such a headache pattern modification 25 . Despite all of those proposed mechanisms, analgesic rebound headache has not been yet demonstrated in placebo-controlled studies with the exception of caffeine.…”

Section: Methodsmentioning

confidence: 99%

Overuse of symptomatic medications among chronic (transformed) migraine patients: profile of drug consumption

Krymchantowski

2003

Arq. Neuro-Psiquiatr.

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-Chronic daily headache and chronic (transformed) migraine (TM) patients represent more than one third of the subjects seen in specialized headache centers. Most of these patients may overuse symptomatic medications (SM) taken on a daily basis to relieve headache and associated symptoms. The conversion to the daily or near-daily pattern of headache presentation is thought to be related to the medication overuse. The aim of this study was to evaluate the profile of SM consumption among transformed migraine patients attending a tertiary center. One hundred thirty three consecutive patients (22 men and 111 women, ages 17 to 80) with TM and overuse of SM according to the proposed criteria of Silberstein et al (1994Silberstein et al ( , 1996 were prospectively studied. None of the patients were under treatment for other conditions. Among them, 73 (54.9%) were using one category of SM, while 55 (41.3%) and 5 (3.8%) patients were taking simultaneously two and three categories of SM respectively. The categories of overused symptomatic medications varied from simple analgesics to narcotics, triptans and combinations of ergot derivatives and caffeine and of analgesics and caffeine. The average intake per patient per day was of 3 to 4 tablets and mostly of the patients overused simple analgesics (isolated or in combination with other substances) (75.2%), caffeine containing drugs (71.4%), drugs containing ergotamine derivatives (26.1%), triptans (alone or combined) (15.5%), drugs with narcotics or ansiolitics (13%) and antiinflammatory drugs (3.7%). The mechanisms by which the overuse of symptomatic medications may play a role in this transformation are uncertain but despite of the necessity of controlled trials to demonstrate the real role of such compounds in the development of transformed migraine, this study emphasizes the necessity for more rigorous prescribing guidelines for patients with frequent headaches.KEY WORDS: chronic (transformed) migraine, overuse, symptomatic medications, analgesic rebound headache.Uso excessivo de medicações sintomáticas em pacientes com migrânea crônica (transformada): perfil Uso excessivo de medicações sintomáticas em pacientes com migrânea crônica (transformada): perfil Uso excessivo de medicações sintomáticas em pacientes com migrânea crônica (transformada): perfil Uso excessivo de medicações sintomáticas em pacientes com migrânea crônica (transformada): perfil Uso excessivo de medicações sintomáticas em pacientes com migrânea crônica (transformada): perfil de consumo medicamentoso de consumo medicamentoso de consumo medicamentoso de consumo medicamentoso de consumo medicamentoso RESUMO -Os pacientes com cefaléia crônica diária e migrânea crônica (transformada) (MT) representam mais de um terço dos pacientes vistos em centros especializados. Muitos destes pacientes abusam de medicações sintomáticas (MS) tomadas em caráter diário para aliviar a cefaléia e/ou os sintomas associados. A conversão para o padrão de apresentação diário ou quase diário parece ser relacionada ao uso e...

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5HT in Migraine Patients with Medication-Induced Headache

Cited by 51 publications

References 13 publications

Relevance of analgesic abuse in the maintenance of chronic headaches

Relevance of analgesic abuse in the maintenance of chronic headaches

Chronic daily headache: biochemical and neurotransmitter abnormalities

Overuse of symptomatic medications among chronic (transformed) migraine patients: profile of drug consumption

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