Untitled

Abstract

Poly(ester-amide)s were prepared by ring-opening copolymerization of L-lactide with glycine anhydride to form poly(lactide-co-glycine) and with alanine anhydride to form poly(lactide-co-alanine). At 195 o C there were about 5.7 mol% inclusion of glycine using potassium tert-butoxide as catalyst in poly(lactideco-glycine) and 5.0 mol% inclusion of alanine using tin(II) bis-2-ethylhexanoate as catalyst in poly(lactideco-alanine). Enzymatic degradation studies showed that both copolymers could be degraded by proteinase K and glycine and alanine were included in their respective copolymers.