5α-androstane-3β,17β-diol in feedback between gonads and hypothalamo-pituitary system of male rats

Loseva, L. A.; Degtiar, V G; Isachenkov, V. A.

doi:10.1016/0022-4731(80)90168-5

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…The obser¬ vation that 3ß-diol was more effective than testoster¬ one, even if less effective than DHT and 3a-diol, in inhibiting LH secretion also confirms previous evi¬ dence (Zanisi et al 1973 ;Martini, Celotti, Juneja et al 1979;Loseva, Degtiar & Isachenkov, 1980;Eckstein et al 1981;Martini, 1982). The fact that testosterone propionate, DHT propionate and 3ß-diol dipropionate were more effective than the respective alcohols in depressing LH release is not surprising, since steroid esters are released from the injection site in a more continuous fashion than 'free' steroids, and consequently may provide more constant serum con¬ centrations of the active principles.…”

Section: Discussionsupporting

confidence: 84%

“…The inefficacy of 3a-and 3ß-diols in modifying hypothalamic LHRH stores of castrated animals shown in this study agrees with previous data ofLoseva et al (1980), who reported that a single injection of these two metabolites into castrated male rats 24 h before death did not modify the LHRH stored in the median eminence. These authors reported a small decline of LHRH in the arcuate nucleus following injection of both 3a-and 3ß-diol, however.The present data clearly show that the 5a-reduced metabolites of testosterone are unable to mimic the effect of testosterone in raising MBH levels of LHRH in castrated rats.…”

supporting

confidence: 94%

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Testosterone metabolites do not participate in the control of hypothalamic LH-releasing hormone

Zanisi¹,

Celotti²,

Ferraboschi³

et al. 1986

Journal of Endocrinology

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To determine whether the ability of testosterone to increase intrahypothalamic LH-releasing hormone (LHRH) in orchidectomized rats might be explained by the conversion of the hormone into either its 5 alpha-reduced or oestrogenic metabolites, testosterone, 5 alpha-androstan-17 beta-ol-3-one (DHT), 5 alpha-androstane-3 alpha,17 beta-diol (3 alpha-diol) and 5 alpha-androstane-3 beta,17 beta-diol (3 beta-diol) (2 mg/rat per day for 6 days) and oestradiol (0.1, 0.5, 1.0 and 5.0 micrograms/rat per day for 6 days) were injected into castrated male rats. After 6 days the rats were killed and serum LH levels and intrahypothalamic LHRH stores measured using specific radioimmunoassay procedures. Testosterone and its 5 alpha-reduced metabolites were used in either the free alcohol or the propionate form (dipropionates in the case of the diols); oestradiol was used as oestradiol-17 beta or in the benzoate form. Treatment with testosterone, DHT, 3 alpha-diol and 3 beta-diol resulted in a significant decrease in serum LH levels; all the 5 alpha-reduced testosterone derivatives were more effective than testosterone in this respect. Testosterone and DHT propionates suppressed LH release following orchidectomy totally; 3 alpha-diol and 3 beta-diol dipropionates were less effective. Testosterone increased intrahypothalamic LHRH stores, this effect being much higher after testosterone propionate, i.e. when intrahypothalamic LHRH stores were restored to pre-castration levels. None of the 5 alpha-reduced steroids was capable of modifying the low intrahypothalamic levels of LHRH found following orchidectomy; only 3 alpha-diol dipropionate exhibited some activity, but this was much lower than that of testosterone propionate. Oestradiol-17 beta was totally ineffective in decreasing serum LH in orchidectomized animals; in contrast, oestradiol benzoate progressively decreased serum LH.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 84%

supporting

confidence: 94%

Testosterone metabolites do not participate in the control of hypothalamic LH-releasing hormone

Zanisi¹,

Celotti²,

Ferraboschi³

et al. 1986

Journal of Endocrinology

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“…Studies of the influence of androgens on gonadotropin secretion revealed sexual dimorphism in their effects on the production of luteinizing hormone in castrated rats [7,8,46]. 3(:t-D and 313-D produced different inhibitory effects on this process that differed also from the effect of testosterone.…”

Section: N N Blokhin Russian Ontological Research Center Russian Amentioning

confidence: 93%

“…In castrated females, single injection of androgens inhibited secretion of luteinizing hormone only for 6 h postinjection or shorter (for 3~-D). In castrated male rats, the effect of androgens persisted longer than in females, but did not exceed 24 h [7,8,46]. Some authors hypothesized that 3(:t-D and 313-D affect DHT binding to rat HPC cells (i.e., androgen receptors).…”

Section: N N Blokhin Russian Ontological Research Center Russian Amentioning

confidence: 96%

Metabolism of androgens in rat pituitary gland and hypothalamus: Catabolism of dihydrotestosterone or transformation of androgen signal?

Degtyar

Kushlinskii

2000

Bull Exp Biol Med

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The role of androgen metabolism and individual androgen metabolites in rat pituitary gland and hypothalamus is discussed on the basis of published data and results of our experiments. It is proposed that metabolism of androgens in these structures is aimed at the formation of not only true sex steroids estradiol-17 beta and 5 alpha-dihydrotestosterone, but also of androgens contributing to the regulation of cell processes, i.e. represents modification (transformation) of androgen signal (testosterone) in target pituitary and hypothalamic cells.

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“…Data from this and other laboratories indicate that DHT and 3a-diol are more effective than testosterone in suppressing LH release (Martini et al -1979; see also Celotti et al -1979a for references). 3o-Diol has also been found by some authors to inhibit LH secretion (Swerdloff et al -1973;Zanisi et al -1973;Kao and Weisz -1975;Celotti et al -1977;Martini et al -1979;Loseva et al -1980). Very little information is available on the effects of these three testosterone derivatives on prolactin secretion.…”

Section: Introductionmentioning

confidence: 98%

Effect of 5α-Reduced Androgens on Prolactin Secretion

et al. 2009

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5α-androstane-3β,17β-diol in feedback between gonads and hypothalamo-pituitary system of male rats

Cited by 8 publications

References 9 publications

Testosterone metabolites do not participate in the control of hypothalamic LH-releasing hormone

Testosterone metabolites do not participate in the control of hypothalamic LH-releasing hormone

Metabolism of androgens in rat pituitary gland and hypothalamus: Catabolism of dihydrotestosterone or transformation of androgen signal?

Effect of 5α-Reduced Androgens on Prolactin Secretion

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