6:2 Fluorotelomer iodide in vitro metabolism by rat liver microsomes: Comparison with [1,2-14C] 6:2 fluorotelomer alcohol

Ruan, Ting; Sulecki, Lisa M.; Wolstenholme, Barry W.; Jiang, Guibin; Wang, Ning; Buck, Robert C.

doi:10.1016/j.chemosphere.2014.02.068

Cited by 14 publications

(1 citation statement)

References 31 publications

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“…Nevertheless, radio-isotopic labeling provides a means of overcoming this by measuring positron emission from radioactive decaying chemicals. Due to low natural abundance and lasting half-life, 14 C was selected to label PFAS precursors in order to trace chemical transformations in environmental and biological trials [10,11,26,42].…”

Section: C-labeling and Detection Techniquesmentioning

confidence: 99%

Methodology for studying biotransformation of polyfluoroalkyl precursors in the environment

Ruan

Lin

Wang

et al. 2015

TrAC Trends in Analytical Chemistry

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A B S T R A C TBiotransformation of polyfluoroalkyl precursors contributes in part to the perfluoroalkyl carboxylates and sulfonates detected in the global environment and biota. Robust sample preparation and sensitive analytical techniques for maximum analyte recovery are essential to identify and to quantify biotransformation products often present at low levels in environmental matrices and experimental systems. This critical review covers current sample-preparation and analytical methods, including extraction, concentration, clean-up and derivatization, mass spectrometry coupled to gas or liquid chromatography, and radioisotope labeling and tracking techniques. We also critically review methodologies for molecular structural elucidation and in-silico prediction of potential transformation products. We describe current knowledge gaps and challenges in studying novel alternative polyfluoroalkyl substances. We discuss future trends on utilizing advanced analytical techniques.

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Section: C-labeling and Detection Techniquesmentioning

confidence: 99%

Methodology for studying biotransformation of polyfluoroalkyl precursors in the environment

Ruan

Lin

Wang

et al. 2015

TrAC Trends in Analytical Chemistry

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Fluorotelomer Alcohols’ Toxicology Correlates with Oxidative Stress and Metabolism

Yang¹,

Meng²,

Chen³

et al. 2020

Reviews of Environmental Contamination and Toxicology

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C6-Perfluorinated Compounds: The New Greaseproofing Agents in Food Packaging

Rice

2015

Curr Envir Health Rpt

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Due to their oleophobic and hydrophobic properties and stability, perfluorinated compounds (PFCs) are used in many applications, particularly as greaseproofing agents for food contact. However, PFCs 8-carbons in length or greater (C8-PFCs) have raised concerns regarding environmental biopersistence, bioaccumulation in humans, and potent toxicity that have resulted in their gradual phase-out for food contact use. Industry has replaced C8-PFCs with shorter-chained C6-based greaseproofing agents, which are intended to have the same favorable physicochemical properties without the problematic toxicological effects in humans and wildlife. Compared with the large body of data available for C8 compounds, however, the available database on toxicity and exposure to the C6 compounds is fairly limited. This article summarizes the information in this database, focusing on aspects of human exposure and potential health risks associated with two types of C6 PFCs found in food packaging: perfluorohexanoic acid (PFHxA) and 6-2 fluorotelomer alcohol (C6-FTOH).

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6:2 Fluorotelomer iodide in vitro metabolism by rat liver microsomes: Comparison with [1,2-14C] 6:2 fluorotelomer alcohol

Cited by 14 publications

References 31 publications

Methodology for studying biotransformation of polyfluoroalkyl precursors in the environment

Methodology for studying biotransformation of polyfluoroalkyl precursors in the environment

Fluorotelomer Alcohols’ Toxicology Correlates with Oxidative Stress and Metabolism

C6-Perfluorinated Compounds: The New Greaseproofing Agents in Food Packaging

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