6.3.4 Noble Metal Added Tin Oxide VOC Sensors as Nonanal Detection for Exhaled Breath Air Monitoring

Itoh, Toshio; Nakashima, Takaomi; Izu, Noriya; Shin, Woosuck; Setoguchi, Yasuhiro; Kato, Kimiko; Toyota, Masashi

doi:10.5162/imcs2012/6.3.4

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…The LOD of studied biosensors (a few ppm) is comparable with the finest sensors from other studies (Table 3); however, the operation of chemoresistive sensors requires high temperature (200-300 • C) [73][74][75][76]. Some sensors, for example, the one designed by Tsujiguchi et al [77], also revealed low LOD but required long exposure time to nonanal (5-24 h) and heating stage [74][75][76]. The closest metrological parameters are exhibited by the sensor designed by Jahangiri-Manesh et al [78].…”

Section: Discussionsupporting

confidence: 79%

“…A decrease in LOD by 16 ppm ± 3 ppm with respect to the original peptide-OBPP4, means approaching the ppb order, which is a step towards the application of this type of biosensors to fast and effective detection of aldehydes as potential biomarkers of respiratory tract diseases. The LOD of studied biosensors (a few ppm) is comparable with the finest sensors from other studies (Table 3); however, the operation of chemoresistive sensors requires high temperature (200-300 • C) [73][74][75][76]. Some sensors, for example, the one designed by Tsujiguchi et al [77], also revealed low LOD but required long exposure time to nonanal (5-24 h) and heating stage [74][75][76].…”

Section: Discussionsupporting

confidence: 77%

“…Chemoresistive, SnO 2 nanosheets; SnO 2 nanosheets and nanoparticles 0.1; 0.05 [74,75] Chemoresistive, Pt-, Pd-, and Au-loaded SnO 2 thick films 0.05 [76] Chemoresistive, functionalized rGO 25 [80] Chemoresistive, Polyetherimide/carbon black 1 [73] Chemoresistive, MIP-AuNPs 4.5 [78] Optical, vanillin 0.125 [77] Piezoelectric, molecularly imprinted sol-gel Several ppm [81] Piezoelectric, peptide 14 [60] Piezoelectric, peptide 2 This study…”

Section: Recognition Lod [Ppm]mentioning

confidence: 99%

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Evaluation of Linkers’ Influence on Peptide-Based Piezoelectric Biosensors’ Sensitivity to Aldehydes in the Gas Phase

Wasilewski

Neubauer

Wojciechowski

et al. 2023

IJMS

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Recent findings qualified aldehydes as potential biomarkers for disease diagnosis. One of the possibilities is to use electrochemical biosensors in point-of-care (PoC), but these need further development to overcome some limitations. Currently, the primary goal is to enhance their metrological parameters in terms of sensitivity and selectivity. Previous findings indicate that peptide OBPP4 (KLLFDSLTDLKKKMSEC-NH2) is a promising candidate for further development of aldehyde-sensitive biosensors. To increase the affinity of a receptor layer to long-chain aldehydes, a structure stabilization of the peptide active site via the incorporation of different linkers was studied. Indeed, the incorporation of linkers improved sensitivity to and binding of aldehydes in comparison to that of the original peptide-based biosensor. The tendency to adopt disordered structures was diminished owing to the implementation of suitable linkers. Therefore, to improve the metrological characteristics of peptide-based piezoelectric biosensors, linkers were added at the C-terminus of OBPP4 peptide (KLLFDSLTDLKKKMSE-linker-C-NH2). Those linkers consist of proteinogenic amino acids: group one: glycine, L-proline, L-serine, and non-proteinogenic amino acids; and group two: β-alanine, 4-aminobutyric acid, and 6-aminohexanoic acid. Linkers were evaluated with in silico studies, followed by experimental verification. All studied linkers enhanced the detection of aldehydes in the gas phase. The highest difference in frequency (60 Hz, non-anal) was observed between original peptide-based biosensors and ones based on peptides modified with the GSGSGS linker. It allowed evaluation of the limit of detection for non-anal at the level of 2 ppm, which is nine times lower than that of the original peptide. The highest sensitivity values were also obtained for the GSGSGS linker: 0.3312, 0.4281, and 0.4676 Hz/ppm for pentanal, octanal, and non-anal, respectively. An order of magnitude increase in sensitivity was observed for the six linkers used. Generally, the linker’s rigidity and the number of amino acid residues are much more essential for biosensors’ metrological characteristics than the amino acid sequence itself. It was found that the longer the linkers, the better the effect on docking efficiency.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 77%

Section: Recognition Lod [Ppm]mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Linkers’ Influence on Peptide-Based Piezoelectric Biosensors’ Sensitivity to Aldehydes in the Gas Phase

Wasilewski

Neubauer

Wojciechowski

et al. 2023

IJMS

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show abstract

“…Apart from the GC-MS method for nonanal detection, SnO 2 nanosheets and their modifications have been developed to detect gaseous nonanal by using a chemiresistor sensor working under the temperature of 250-300 °C. [11][12][13][14] For other chemiresistors working under room temperature, materials based on functionalized rGO and polyetherimide/carbon black have been explored for gaseous nonanal detection at ppm level concentrations. 15,16 Moreover, Tsujiguchi and coworkers 17 demonstrated nonanal detection under an aldol condensation reaction inside alkali-resistant porous glass providing absorbance changes.…”

Section: Introductionmentioning

confidence: 99%

A fluorescence-based sweat test sensor in a proof-of-concept clinical study for COVID-19 screening diagnosis

Thaveesangsakulthai

Jongkhumkrong

Chatdarong

et al. 2023

Analyst

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6.3.4 Noble Metal Added Tin Oxide VOC Sensors as Nonanal Detection for Exhaled Breath Air Monitoring

Cited by 2 publications

References 6 publications

Evaluation of Linkers’ Influence on Peptide-Based Piezoelectric Biosensors’ Sensitivity to Aldehydes in the Gas Phase

Evaluation of Linkers’ Influence on Peptide-Based Piezoelectric Biosensors’ Sensitivity to Aldehydes in the Gas Phase

A fluorescence-based sweat test sensor in a proof-of-concept clinical study for COVID-19 screening diagnosis

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