6,8-(1,3-Diaminoguanidine) luteolin and its Cr complex show hypoglycemic activities and alter intestinal microbiota composition in type 2 diabetes mice

Ge, Xiaodong; He, Xiaoyu; Lin, Zhenshan; Zhu, Yuxian; Jiang, Xiaoqin; Zhao, Ludan; Zeng, Feng; Li-gen, Chen; Xu, Wei; Liu, Tingting; Chen, Zhigang; Zhao, Chao; Huang, Ying; Liu, Bin

doi:10.1039/d2fo00021k

Cited by 18 publications

(11 citation statements)

References 63 publications

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“…Therefore, it was indicated that the SVM could prevent the formation of free fatty acids by reducing the accumulation of fat, 40 which was consistent with the previous research. 41…”

Section: Resultsmentioning

confidence: 99%

Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice

Huang

Liu

et al. 2022

Food Funct.

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“…Therefore, it was indicated that the SVM could prevent the formation of free fatty acids by reducing the accumulation of fat, 40 which was consistent with the previous research. 41…”

Section: Resultsmentioning

confidence: 99%

Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice

Huang

Liu

et al. 2022

Food Funct.

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“…Second, new compounds with obvious hypoglycemic effects may be obtained by structural modification of some natural products, which greatly expands the ideas of drug development. For example, 6,8-(1,3-diaminoguanidine) luteolin, a luteolin derivative, increased the abundance of Ruminiclostridium and decreased the abundance of Lachnoclostridium and Parabacteroides , thereby improving glucose metabolism in T2DM mice . Finally, given the complexity of host-gut microbiota crosstalk, elucidation of the molecular mechanisms underlying the protective effects of these natural products on DM is still a long way off.…”

Section: Future Perspectivementioning

confidence: 99%

Preclinical Studies of Natural Products Targeting the Gut Microbiota: Beneficial Effects on Diabetes

Jiang

Sun

Zhou

2022

J. Agric. Food Chem.

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Diabetes mellitus (DM) is a serious metabolic disease characterized by persistent hyperglycemia, with a continuously increasing morbidity and mortality. Although traditional treatments including insulin and oral hypoglycemic drugs maintain blood glucose levels within the normal range to a certain extent, there is an urgent need to develop new drugs that can effectively improve glucose metabolism and diabetes-related complications. Notably, accumulated evidence implicates that the gut microbiota is unbalanced in DM individuals and is involved in the physiological and pathological processes of this metabolic disease. In this review, we introduce the molecular mechanisms by which the gut microbiota contributes to the development of DM. Furthermore, we summarize the preclinical studies of bioactive natural products that exert antidiabetic effects by modulating the gut microbiota, aiming to expand the novel therapeutic strategies for DM prevention and management.

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“…We extracted genomic DNA from intestinal contents according to the method of Ge et al [ 68 ]. We amplified the V3−V4 region of the bacterial 16S rRNA gene using universal primers 338F and 806R.…”

Section: Methodsmentioning

confidence: 99%

Probiotics-Fermented Grifola frondosa Total Active Components: Better Antioxidation and Microflora Regulation for Alleviating Alcoholic Liver Damage in Mice

He¹,

Zhu

Jiang

et al. 2023

IJMS

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Alcoholic liver damage is caused by long-term drinking, and it further develops into alcoholic liver diseases. In this study, we prepared a probiotic fermentation product of Grifola frondosa total active components (PFGF) by fermentation with Lactobacillus acidophilus, Lactobacillus rhamnosus, and Pediococcus acidilactici. After fermentation, the total sugar and protein content in the PFGF significantly decreased, while the lactic acid level and antioxidant activity of the PFGF increased. Afterward, we investigated the alleviating effect of PFGF on alcoholic liver injury in alcohol-fed mice. The results showed that the PFGF intervention reduced the necrosis of the liver cells, attenuated the inflammation of the liver and intestines, restored the liver function, increased the antioxidant factors of the liver, and maintained the cecum tissue barrier. Additionally, the results of the 16S rRNA sequencing analysis indicated that the PFGF intervention increased the relative abundance of beneficial bacteria, such as Lactobacillus, Ruminococcaceae, Parabacteroids, Parasutterella, and Alistipes, to attenuate intestinal inflammation. These results demonstrate that PFGF can potentially alleviate alcoholic liver damage by restoring the intestinal barrier and regulating the intestinal microflora.

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6,8-(1,3-Diaminoguanidine) luteolin and its Cr complex show hypoglycemic activities and alter intestinal microbiota composition in type 2 diabetes mice

Abstract: Flavonoid compounds such as luteolin exhibit hypolipidemic effects, and there are few reports on the hypoglycemic activity of luteolin derivatives. In this research, 6, 8-(1, 3-diaminoguanidine) luteolin (DAGL) and its...

Cited by 18 publications

References 63 publications

Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice

Sanghuangporus vaninii mixture ameliorated type 2 diabetes mellitus and altered intestinal microbiota in mice

Preclinical Studies of Natural Products Targeting the Gut Microbiota: Beneficial Effects on Diabetes

Probiotics-Fermented Grifola frondosa Total Active Components: Better Antioxidation and Microflora Regulation for Alleviating Alcoholic Liver Damage in Mice

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