6. Clinical aspects of histamine

Tetlow, Lesley; Woolley, David

doi:10.1007/s00011-004-0434-6

Cited by 1 publication

(1 citation statement)

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“…The presence of mast cells in the joints has been known (22,(146)(147)(148)(149)(150)(151)(152) but the increasing role of mast cells in inflammatory arthritis was reviewed only recently (153). The accumulation of mast cells in the joints may be owing to the local release of chemoattractants, such as RANTES and MCP-1 (14) found in joints of patients with arthrosynovitis (154).…”

Section: Inflammatory Arthritismentioning

confidence: 99%

Human umbilical cord blood-derived mast cells

et al. 2006

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Findings obtained using animal models have often failed to reflect the processes involved in human disease. Moreover, human cultured cells do not necessarily function as their actual tissue counterparts. Therefore, there is great demand for sources of human progenitor cells that may be directed to acquire specific tissue characteristics and be available in sufficient quantities to carry out functional and pharmacological studies. Acase in point is the mast cell, well known for its involvement in allergic reactions, but also implicated in inflammatory diseases. Mast cells can be activated by allergens, anaphylatoxins, immunoglobulin-free light chains, superantigens, neuropeptides, and cytokines, leading to selective release of mediators. These could be involved in many inflammatory diseases, such as asthma and atopic dermatitis, which worsen by stress, through activation by local release of corticotropin-releasing hormone or related peptides. Umbilical cord blood and cord matrix-derived mast cell progenitors can be separated magnetically and grown in the presence of stem cell factor, interleukin-6, interleukin-4, and other cytokines to yield distinct mast cell populations. The recent use of live cell array, with its ability to study such interactions rapidly at the single-cell level, provides unique new opportunities for fast output screening of mast cell triggers and inhibitors.

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