6-[F-18]Fluoro-<scp>l</scp>-Dihydroxyphenylalanine Positron Emission Tomography Is Superior to Conventional Imaging with 123I-Metaiodobenzylguanidine Scintigraphy, Computer Tomography, and Magnetic Resonance Imaging in Localizing Tumors Causing Catecholamine Excess

Fiebrich, Helle-Brit; Brouwers, Adrienne H.; Kerstens, Michiel N.; Pijl, Milan E. J.; Kema, Ido P.; Jong, Johan R. de; Jager, Pieter L.; Elsinga, Philip H.; Dierckx, Rudi; Wal, Jacqueline E. van der; Sluiter, Wim J.; Vries, Elisabeth G.E. de; Links, Thera P.

doi:10.1210/jc.2009-1054

Cited by 146 publications

(87 citation statements)

References 33 publications

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“…Overall sensitivity and specificity in detecting pheochromocytoma were 100% and 89%. A combination of 18 F-FDOPA PET/ CT and CT/MRI was found to be the optimal imaging strategy in another study (56). 18 F-FDOPA PET has also been used to identify metastases from medullary thyroid carcinomas in MEN2 patients (50).…”

Section: Men2-related Pheochromocytomasmentioning

confidence: 94%

Modern Nuclear Imaging for Paragangliomas: Beyond SPECT

et al. 2012

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Learning Objectives: On successful completion of this activity, participants should be able to describe (1) the best nuclear imaging procedures to detect pheochromocytomas/paragangliomas according to the clinical situation (e.g., sporadic vs. hereditary; primary vs. metastatic; sympathetic vs. parasympathetic) and (2) the differences in the phenotypic information obtained by various PET tracers.Financial Disclosure: The authors of this article have indicated no relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNM is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNM designates each JNM continuing education article for a maximum of 1.0 AMA PRA Category 1 Credit. Physicians should claim only credit commensurate with the extent of their participation in the activity.For CE credit, participants can access this activity through the SNM Web site (http://www.snm.org/ce_online) through February 2013.Paragangliomas are rare neuroendocrine tumors that may arise anywhere along the paraganglial system, with a high frequency of hereditary forms or multifocal disease. Most often, paragangliomas are benign and progress slowly, but metastases may occur in about 10% of patients. In this respect, nuclear imaging in combination with anatomic imaging may be required to fully delineate the extent of the disease. PET has been increasingly used in imaging paraganglioma, paralleled by great efforts toward the development of new tracers. Recent data indicate that the choice of PET tracers should be tailored to tumor localization and to the patient's genetic status. This article provides insight into the many PET radiotracers that are currently available and others that are still only under research and guides clinicians toward appropriate use in relation to genetic carrier status. In addition, this article provides nuclear medicine physicians with the background knowledge required for understanding relationships between imaging phenotypes and molecular genetics.

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Section: Men2-related Pheochromocytomasmentioning

confidence: 94%

Modern Nuclear Imaging for Paragangliomas: Beyond SPECT

et al. 2012

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“…Furthermore, 18 F-DOPA PET and PET/CT seem to be accurate methods in both sporadic and inherited PG [27,30], except in SDHB-related PG [28].…”

Section: Diagnostic Performancementioning

confidence: 96%

“…The baseline differences among the patients in the included studies (Table 1) Nevertheless, according to the literature, 18 F-DOPA PET and PET/CT seem to be accurate methods in both adrenal [22,25,26,29] and extra-adrenal [23,24,30,31], sympathetic [22,[25][26][27] and parasympathetic [23,24,30,31], functioning [27] and non-functioning [23,26,31], metastatic and non-metastatic tumors [24,28,32]. Furthermore, 18 F-DOPA PET and PET/CT seem to be accurate methods in both sporadic and inherited PG [27,30], except in SDHB-related PG [28].…”

Section: Diagnostic Performancementioning

confidence: 98%

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Diagnostic performance of 18F-dihydroxyphenylalanine positron emission tomography in patients with paraganglioma: a meta-analysis

Treglia

Cocciolillo

Waure

et al. 2012

Eur J Nucl Med Mol Imaging

101

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“…Como a sensibilidade dos exames de imagem descritos é ainda menor na presença de tumores extrassuprarrenais, metastáticos e recorrentes, torna-se fundamental a realização de um estudo funcional adicional, sendo a cintilografia com 123-metaiodobenzilguanida o exame de eleição, uma vez que essa substância apresenta grande afinidade pela medula suprarrenal, o tecido nervoso adrenérgico e as células do feocromocitoma [7,9,32,36,37]. No caso do diagnóstico permanecer equívoco, podem-se realizar outros métodos, como a tomografia por emissão de positrons [6,7,38,39].…”

Section: /10unclassified

Quando hipertensão arterial persistente no adolescente tem uma origem endócrina rara: relato de dois casos e revisão da literatura

Gomes

Laranjo

Santos

et al. 2017

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. ABSTRACT AIMS: To report two clinical cases of pheochromocytoma, a rare tumor in the pediatric population, that affects the adrenal medulla, is malignant in up to 47% of cases, and whose clinical manifestations result from hypersecretion of catecholamines. CASE DESCRIPTION: Two cases of pheochromocytoma in adolescents are described, both with persistent hypertension and one with headache, sweating, and tachycardia. Renal and adrenal ultrasound, computed tomography angiography, and measurements of catecholamines and their metabolites revealed pheochromocytoma in the left adrenal gland. Adrenalectomy was performed after pretreatment with α-blockers. Pathological examination confirmed the diagnosis. Blood pressure returned to normal in both patients after treatment. CONCLUSIONS: Pheochromocytoma has a varied and nonspecific clinical presentation, but this condition should always be considered in the differential diagnosis of high blood pressure. Early diagnosis may imply a less aggressive treatment, lower morbidity, and a lesser impact on patients' quality of life. The high likelihood of recurrence of pheochromocytoma, including as metastatic disease, requires follow-up visits for several years after its initial clinical presentation, even in the case of an apparent cure.

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6-[F-18]Fluoro-l-Dihydroxyphenylalanine Positron Emission Tomography Is Superior to Conventional Imaging with 123I-Metaiodobenzylguanidine Scintigraphy, Computer Tomography, and Magnetic Resonance Imaging in Localizing Tumors Causing Catecholamine Excess

Cited by 146 publications

References 33 publications

Modern Nuclear Imaging for Paragangliomas: Beyond SPECT

Modern Nuclear Imaging for Paragangliomas: Beyond SPECT

Diagnostic performance of 18F-dihydroxyphenylalanine positron emission tomography in patients with paraganglioma: a meta-analysis

Quando hipertensão arterial persistente no adolescente tem uma origem endócrina rara: relato de dois casos e revisão da literatura

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