[6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo

Kim, Eok Cheon; Kim, Jung Min; Kim, Tae Yoon; Lee, Shin Jeong; Yang, Hyun Ok; Han, Sim-Hee; Kim, Young Myeong; Kwon, Young Guen

doi:10.1016/j.bbrc.2005.07.076

Cited by 248 publications

(174 citation statements)

References 27 publications

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“…Esculetin (36) has been shown to induce apoptosis in various human cancer cells [77] and, more particularly, U937 human leukemia cells [78]. This anticancer activity was associated with selective activation of the phosphorylation of extracellular-regulated kinase (ERK) and c-Jun Nterminal kinase (JNK) [78].…”

Section: Coumarinsmentioning

confidence: 99%

Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

Lamoral-Theys¹,

Pottier

Dufrasne³

et al. 2010

CMC

124

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Over eleven hundred publications reporting anticancer activities of polyphenols have appeared in the peerreviewed literature. In addition, a search of the PubMed database using "polyphenols -cancer -review" as keywords produced over 320 hits for review articles (July 2009). Polyphenol anticancer activities include, among others, anti-oxidative, pro-apoptotic, DNA damaging, anti-angiogenic, and immunostimulatory effects. Targeting specific protein kinases to combat cancer represents a major focus of oncology research within the so-called targeted therapy approach. An exhaustive search of the PubMed database (July 2009) using "polyphenols -cancer -kinases" as keywords resulted in more than 130 hits, half of them having been published within the past five years. Furthermore, the PubMed database contains 25 reviews on the subject of anti-kinase activity of some specific polyphenols, including mainly curcumin and the green tea polyphenol (-)-epigallocatechin 3-gallate (EGCG). However, no attempt has been made yet to review this area of research in a comprehensive, general manner. The current review therefore aims to highlight those anticancer polyphenols that target specific kinases in various types of cancer. The present review also provides an in-depth analysis of polyphenol structure-activity relationships in relation to their anticancer activities and specific kinase targeting. Lastly, a number of polyphenols are identified as potential antitumor agents that could be used to combat biologically aggressive cancers, including metastasizing cancers, through the targeting of specific kinases.

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Section: Coumarinsmentioning

confidence: 99%

Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

Lamoral-Theys¹,

Pottier

Dufrasne³

et al. 2010

CMC

124

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“…Among various types of gingerols, 6-ginge rol ( Fig. 1) identified by Jolad et al [2004] is one of the most pharmacologically active and abundant components [Kim et al 2005]. The presence of α-, β-hydroxy keto functional group in the structure of gingerols makes them susceptible to transformation to shogaol and zingerone at high temperature and long drying times [Bhattarai et al 2001, Balladin et al 1998, Jiang et al 2007].…”

Section: Introductionmentioning

confidence: 99%

“…The presence of α-, β-hydroxy keto functional group in the structure of gingerols makes them susceptible to transformation to shogaol and zingerone at high temperature and long drying times [Bhattarai et al 2001, Balladin et al 1998, Jiang et al 2007]. Based on previous reports, 6-gingerol has a wide array of biochemical and pharmacologic activities, including anti-oxidant, anti-inflammatory, analgesic, anti-mutagenic [Shukla et al 2007], anti-angiogenesis [Kim et al 2005], anti-emetic [Abdel-Aziz et al 2006], anti-hyperglycemic [Chakraborty et al 2012], and anticancer activities in vitro and in vivo [Lee et al 2008, Nigam et al 2009, Yang et al 2010.…”

Section: Introductionmentioning

confidence: 99%

Optimized microwave-assisted extraction of 6-gingerol from Zingiber officinale Roscoeand evaluation of antioxidant activity in vitro

Liu¹,

Zhou²,

Zhao³

et al. 2014

Acta Sci Pol Technol Aliment

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Background. 6-Gingerol is one of the most pharmacologically active and abundant components in ginger, which has a wide array of biochemical and pharmacologic activities. In recent years, the application of microwave-assi sted extraction (MAE) for obtaining bioactive compounds from plant materials has shown tremendous research interest and potential. In this study, an effi cient microwave-assisted extraction (MAE) technique was developed to extract 6-gingerol from ginger. The extraction effi ciency of MAE was also compared with conventional extraction techniques. Material and methods. Fresh gingers (Zingiber officinale Rosc.) were harvested at commercial maturity (originally from Shandong, laiwu, China). In single-factor experiments for the recovery of 6-gingerol, proper ranges of ratio of liquid to solid, ethanol proportion, microwave power, extraction time were determined. Based on the values obtained in single-factor experiments, a Box-Behnken design (BBD) was applied to determine the best combination of extraction variables on the yield of 6-gingerol. Results. The optimum extraction conditions were as follows: mi crowave power 528 W, ratio of liquid to solid 26 mL·g -1 , extraction time 31 s and ethanol proportion 78%. Furthermore, more 6-gingerol and total polyphenols contents were extracted by MAE than conventional methods including Maceration (MAC), Stirring Extraction (SE), Heat reflux extraction (HRE), Ultrasound-assisted extraction (UAE), as well as the antioxidant capacity. Conclusion. Microwave-assisted extraction showed obvious advantages in terms of high extraction efficiency and antioxidant activity of extract within shortest extraction time. Scanning electron microscopy (SEM) images of ginger powder materials after different extractions were obtained to provide visual evidence of the disruption effect. To our best knowledge, this is the fi rst report about usage of MAE of 6-gingerol extraction from ginger, which could be referenced for the extraction of other active compounds from herbal plants.

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“…Ziziphus spina-christi L., commonly known by the Persian names "konar" or "sedr", is widely grown in the South of Iran. The antibacterial, antiviral and antidiabetic effects of the extracts or fractions of the leaves of this plant are confirmed (20). Flavonoids, alkaloids, tannins, sterols, betulinic acid and triterpenoidal saponin glycosides are isolated from different species of Ziziphus (21).…”

Section: Introductionmentioning

confidence: 87%

“…Ginger is produced from the rhizome of Zingiber officinale. Gingerol is an active component of ginger and responsible for antibacterial, anti-angiogenic, anti-inflammatory and anti-tumor promoting activities (19,20). Antioxidant molecules already reported from this plant are alflabene, cassumunene, cassumunaquinones I, II, cassumunins a, B, C and cassumunarins a, B, C (4).…”

Section: Introductionmentioning

confidence: 99%

Optimal Concentrations and Synergistic Effects of Some Herbal Extracts on Viability of Dermal Fibroblasts

et al. 2016

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[6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo

Cited by 248 publications

References 27 publications

Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

Optimized microwave-assisted extraction of 6-gingerol from Zingiber officinale Roscoeand evaluation of antioxidant activity in vitro

Optimal Concentrations and Synergistic Effects of Some Herbal Extracts on Viability of Dermal Fibroblasts

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