6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction

Li, Jinxiu; Wang, Shang; Yao, Ling; Ma, Peng; Chen, Zhiwei; Han, Ting‐Li; Yuan, Chunlin; Zhang, Jun; Jiang, Lirong; Liu, Li; Ke, Danxia; Li, Chunli; Yamahara, Johji; Li, Yuhao; Wang, Jianwei

doi:10.1016/j.taap.2018.11.001

Cited by 44 publications

(20 citation statements)

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“…A few studies have reported its molecular effects on age-related non-alcoholic fatty liver disease (NAFLD), as well as on epigenetic factors. In an in vivo recent study in aged rats, Li et al demonstrated that 6-gingerol brought to normal the hepatic TG content, plasma insulin and HOMA-IR index of ageing rats [303]. Mechanistically, they showed that 6-gingerol modulates lipid metabolism by increasing β-oxidation and decreasing lipogenesis, through activation of liver PPARα and carnitine palmitoyl-transferase 1α (CPT1α), and inhibition of diacylglycerol O-acyltransferase 2 (DGAT-2) expression at translational level, but not at transcriptional level, to ameliorate ageing-associated hepatosteatosis.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, 6-gingerol showed minimal effect on hepatic miR-34a. Additionally, 6-gingerol significantly decreased hepatic miR-107-3p level, thereby increasing PPARα and CPT1α genes [303]. Kim et al investigated molecular factors involved in lipid metabolism and inflammation of the white adipose tissue (WAT), including miRNAs, modulated by GEx in Sprague-Dawley rats fed a high-fat diet [304].…”

Section: Discussionmentioning

confidence: 99%

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Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

et al. 2020

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Atherosclerosis is the main process behind cardiovascular diseases (CVD), maladies which continue to be responsible for up to 70% of death worldwide. Despite the ongoing development of new and potent drugs, their incomplete efficacy, partial intolerance and numerous side effects make the search for new alternatives worthwhile. The focus of the scientific world turned to the potential of natural active compounds to prevent and treat CVD. Essential for effective prevention or treatment based on phytochemicals is to know their mechanisms of action according to their bioavailability and dosage. The present review is focused on the latest data about phenolic compounds and aims to collect and correlate the reliable existing knowledge concerning their molecular mechanisms of action to counteract important risk factors that contribute to the initiation and development of atherosclerosis: dyslipidemia, and oxidative and inflammatory-stress. The selection of phenolic compounds was made to prove their multiple benefic effects and endorse them as CVD remedies, complementary to allopathic drugs. The review also highlights some aspects that still need clear scientific explanations and draws up some new molecular approaches to validate phenolic compounds for CVD complementary therapy in the near future.In the last decade the scientific researchers turned their attention to phytochemicals, as effective, safe and low-cost natural bioactive compounds for CVD treatment.Dyslipidemia consists of increased blood concentrations of total cholesterol (TC), low density lipoproteins-cholesterol (LDL-C) and/or triglycerides (TG), and decreased high density lipoproteins-cholesterol (HDL-C) [6]. The lipid metabolism is complex and the candidate mechanisms that could generate dyslipidemia include: (i) excessive dietary lipid absorption in the small intestine; (ii) packing of exogenous lipids with cholesterol and fatty acids produced de novo in the liver and their secretion as very low density lipoproteins (VLDL); (iii) hydrolysis of TG from VLDL by lipases and their conversion into LDL, which are taken up by the peripheral tissues through LDL receptor (LDL-R) and scavenger receptors; (iv) diminished production of HDL by the liver and small intestine, thereby decreasing reverse cholesterol transport (RCT) from the peripheral tissues to the liver; (v) lowered excess cholesterol excretion from the liver into gallbladder or to the intestinal lumen through the ATP-binding cassette G5 and G8 transporters (ABCG5/G8) that facilitate trans-intestinal cholesterol efflux (TICE). Dyslipidemia is associated with the accumulation of LDL in the sub-endothelium of the artery wall. At this site, LDL undergoes oxidative modifications (oxLDL) that trigger inflammatory responses, and is taken up by the monocyte-derived macrophages infiltrated in the sub-endothelium which thus become lipid-loaded foam cells, the hallmark of atheroma development [7]. Until now, the most effective lipid-lowering treatment for hyperlipidemic patients was the statin therapy. But recen...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

et al. 2020

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“…Yang et al [62] also stated that improved Haugh unit was accompanied by increased blood antioxidant enzymes in birds fed ginger root. This may be explained by the radical-scavenging effect of phenolic compounds and antioxidant components in ginger extract, which reduce lipid oxidation [63] and enhance the function of body organs as partly reflected by decreased the serum activities of ALT and AST, thus improving the production and synthesis of antioxidant enzymes [64]. On the same line, Gurbuz and Salih [65] found that powder of ginger root lowered yolk cholesterol content.…”

Section: Effect Of Ginger On Meat and Egg Qualitymentioning

confidence: 97%

Ginger and Its Derivatives as Promising Alternatives to Antibiotics in Poultry Feed

El‐Hack

Alagawany

Shaheen

et al. 2020

Animals

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Simple Summary: The present review updates the current knowledge about the beneficial effects of ginger and its derivatives as feed supplements to poultry feed, particularly its positive effects on the body weight, carcass traits, egg production and quality, reproductive performance, blood parameters, egg and meat quality and microbiological aspects as well as the economic efficiency.Abstract: Poultry enterprises have sustained rapid development through the last three decennaries. For which reason, higher utilization of antibacterial, either as therapeutic or growth promoting agents, has been accepted. Owing to the concern of developing bacterial resistance among populations towards antibiotic generations, accumulation of antibacterial remaining's in chicken products and elevating shopper request for outcomes without antibacterial remaining's, looking for unconventional solutions that could exchange antibacterial without influencing productiveness or product characters. Using natural alternatives including ginger, garlic prebiotics, organic acids, plant extracts, etheric oils and immune stimulants have been applied to advance the performance, hold poultry productiveness, prevent and control the enteric pathogens and minimize the antibacterial utilization in the poultry production in recent years. The use of a single replacement or ideal assemblage of different choices besides good supervision and livestock welfare may play a basic role in maximizing benefits and preserving poultry productiveness. The object of this review was to support an outline of the recent knowledge on the use of the natural replacements (ginger and its derivatives) in poultry feed as Animals 2020, 10, 452 2 of 16 feed additives and their effects on poultry performance, egg and meat quality, health as well as the economic efficiency.

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“…Gingerols were proven to alleviate oxidative stress of animals induced by mycotoxins, heavy metals, aging, etc. [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Effects of Ginger Extract on Laying Performance, Egg Quality, and Antioxidant Status of Laying Hens

Cui

Tao³

et al. 2019

Animals

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Simple SummaryThe application of in-feed antibiotic growth promoters was banned in many countries due to their negative effects, and several kinds of feed additives were widely investigated as antibiotic alternatives, in which natural plant-derived products received much attention due to their environmentally friendly properties and numerous biological activities. Ginger (Zingiber officinale Roscoe), a widely used herbal medicine and spice, was proven to have potential as an antibiotic alternative in poultry feed, but there is little literature on the efficacy of ginger extract (GE), which has concentrated bioactive compounds with high bioavailability. Our results showed that dietary GE supplementation increased egg weight, improved egg quality, and reduced the yolk cholesterol content of laying hens. Decreased serum activities of alanine transaminase and aspartate transaminase and improved antioxidant status were observed in the GE group. Our study demonstrated the potential benefits of GE in laying hens.AbstractThe objective of this study was to investigate the effects of ginger extract (GE) as a dietary supplement for laying hens. A total of 40-week-old 288 Hyline Brown laying hens were randomly divided into two groups with six replicates, and fed a basal diet with or without 100 g/t GE for eight weeks. Dietary GE supplementation increased egg weight, albumin height, and Haugh unit of eggs, and decreased yolk cholesterol content and activities of alanine transaminase and aspartate transaminase in serum at eight weeks. Moreover, GE resulted in higher total superoxide dismutase (T-SOD) activity and lower malondialdehyde (MDA) content in yolk at four and eight weeks and in serum. It was concluded that GE was effective in increasing egg weight and improving the egg quality and antioxidant status of laying hens.

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6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction

Cited by 44 publications

References 43 publications

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

Phenolic Compounds Exerting Lipid-Regulatory, Anti-Inflammatory and Epigenetic Effects as Complementary Treatments in Cardiovascular Diseases

Ginger and Its Derivatives as Promising Alternatives to Antibiotics in Poultry Feed

Effects of Ginger Extract on Laying Performance, Egg Quality, and Antioxidant Status of Laying Hens

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