6-Gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice

Sabina, Evan Prince; Pragasam, Samuel Joshua; Kumar, Suresh; Rasool, Mahaboobkhan

doi:10.3736/jcim20111116

Cited by 45 publications

(19 citation statements)

References 26 publications

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“…[27] In conclusion, Zingiber officinale affected the bioavailability, kinetics of the metal assimilation, uptake and excretion in a time-dependant manner, with more hepatic protection to Cd and less to Hg and Pb, as such it is beneficial for the reduction of heavy metal burden. Our results highlight the hepatoprotective effect of this nutrient substance against heavy metals, these hepatoprotective effects against other chemicals that induce hepatic stress and hepatotoxicity have been reported by other researchers[22272842–44] and our studies further confirm it. Our limitations include the non-observance of the toxicokinetics of these metals due to treatment with the nutrient substances and the bioaccumulation of these metals in other tissues.…”

Section: Discussionsupporting

confidence: 90%

Comparative study on the hepatoprotection to heavy metals of Zingiber officinale

Nwokocha¹,

Owu²,

Nwokocha³

et al. 2012

Phcog Res

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Context:Zingiber officinale (Zingiberaceae) is a herb used for culinary and therapeutic purposes due to its anti-inflammatory and antioxidant potentials.Objectives:We examined its protective ability against mercury (Hg), lead (Pb) and cadmium (Cd) accumulation in the liver.Materials & Methods:Ground Zingiber officinale (7%, w/w of feed) was administered to rats either at the same time with the exposure ofheavy metals (group 2), a week after exposure to heavy metals (group 3) or given a week before heavy metal exposure (group 4) for six weeks. Animals were exposed to either of Hg (10 ppm), Cd (200 ppm) and Pb (100 ppm) in drinking water. The heavy metal accumulations in the liver were determined using AAS.Results:Weight losses induced by these metals were not reversed by Zingiber officinale administration. There was a significant (P<0.01) increase in protection to Pb (97%) and Cd (63%) accumulation when compared to Hg (32%) at week 2. The protective ability was significantly (P<0.01) decreased at week 4 when compared to week 2 for Cd and Pb but not to Hg in groups 3 (50%) and 4 (52%). At week 6, hepatoprotection to Hg (44%) and Cd (85%) was significantly (P<0.01) different but not to Pb which was only significant (P<0.05) in week 2 of treatment for all groups.Discussion and Conclusion:Zingiber officinale affected the bioavailability, elimination and uptake of these metals in a time-dependent way with highest beneficial reducing effect to Cd followed by Hg and least protection to Pb in the liver.

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Section: Discussionsupporting

confidence: 90%

Comparative study on the hepatoprotection to heavy metals of Zingiber officinale

Nwokocha¹,

Owu²,

Nwokocha³

et al. 2012

Phcog Res

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“…The lowering of total bilirubin and several hepatic marker enzymes, including aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase, in blood serum indicated that 6-GN possesses hepatoprotective activity at a dose of 30 mg/kg, against acetaminophen-induced hepatotoxicity (Sabina et al, 2011). These effects were similar to those achieved with silymarin, the positive control, at a dose of 25 mg/kg.…”

Section: Hepatoprotective Activitymentioning

confidence: 63%

Gingerols and shogaols: Important nutraceutical principles from ginger

et al. 2015

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“…This effect is seen due to its action on the 5-HT3 receptor (Ajith et al, 2007;Krim et al, 2013;Waggas, 2009;Sabina et al, 2011;Ahmed et al, 2008).…”

Section: Ginger Anti-nausea Effect Due To Chemotherapymentioning

confidence: 99%

Potential health benefits and scientific review of ginger

Al-Awwadi¹

2017

J. Pharmacognosy Phytother.

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Ginger has been known for its several scientific properties and valued for the last 2500 years in different parts of the globe. Ginger has rich phytochemistry and several health promoting perspectives. In ginger family, Zingiber officinalis is one of most widely used species and it is found in several foods and beverages. Ginger has been used commonly to treat diarrhea, stomach upset, indigestion and nausea. It also has anti-inflammatory and antioxidant properties. Ginger constituents are 80% moisture, 2% protein, 2% fiber, 1% mineral, 0.9% fat, and 12% carbohydrate. The chemistry of ginger is well documented with the respect to the oleoresin and volatile oil. It is concluded that, ginger has potential to treat numerous disorders including cancer due to its anti-inflammatory and anti-oxidant properties. It is also useful in controlling the process of aging. This scientific review favors ginger due to its rich phytochemistry; however, due to some ambiguities, it is recommended to conduct clinical trials of ginger with sound protocol design before claiming its efficacy.

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6-Gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice

Cited by 45 publications

References 26 publications

Comparative study on the hepatoprotection to heavy metals of Zingiber officinale

Comparative study on the hepatoprotection to heavy metals of Zingiber officinale

Gingerols and shogaols: Important nutraceutical principles from ginger

Potential health benefits and scientific review of ginger

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