6-Methyl-N'-(1-methylethylidene)imidazo[2,1-b][1,3]thiazole-5-carbohydrazide monohydrate

Abstract

Key indicatorsSingle-crystal X-ray study T = 293 K Mean (C-C) = 0.003 Å R factor = 0.039 wR factor = 0.107 Data-to-parameter ratio = 15.7For details of how these key indicators were automatically derived from the article, see

N-(2,2-Dimethyl-4-oxo-1,3-thiazolidin-3-yl)-6-methylimidazo[2,1-b][1,3]thiazole-5-carboxamide monohydrate

“…The mean C-S bond length [1.7588 (5) Å ] is longer than distances reported for similar molecules [1.729 (2) (Akkurt et al, 2005) and 1.739 (5) Å (Vasu et al, 2004)]. The other bond lengths and angles are in agreement with expected values (Allen et al, 1987).…”

3,4-Di-p-tolyl-6,7-dihydroimidazo[2,1-b][1,3]thiazole

“…This value is close to those found for other structures including an imidazo-thiazole ring system [e.g. 1.38 (9) (Akkurt et al, 2005) and 0.38 (9) (Ö ztü rk Yıldırım et al, 2005)]. The benzene rings are twisted out of the imidazole ring plane and make dihedral angles of 20.5 (2) and 49.3 (2) with the imidazole ring.…”

“…The difference between these bond lengths can be attributed to the different hybridization of the Csp 3 and Csp 2 atoms. The N4-C5 and N4-C7 distances are in good agreement, but the N7-C7 bond is slightly shorter and the N7-C6 bond is slightly longer than distances reported for similar structures (Akkurt et al, 2005;Ö ztü rk Yıldırım et al, 2005).…”

6-Methyl-N-(3-oxo-1-thia-4-azaspiro[4.4]non-4-yl)imidazo[2,1-b][1,3]thiazole-5-carboxamide monohydrate

“…The discovery of the immunomodulatory properties of levamisole [(À)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole; Devlin & Hargrave, 1989] has provoked a great deal of research on imidazo[2,1-b]thiazole derivatives. In connection with our previous papers on the synthesis of imidazo[2,1-b]thiazoles and their crystal structures (Akkurt et al, 2005;, we report here the crystal structure of the title spiro derivative, 6-methyl-N-(3oxo-1-thia-4-azaspiro[4.4]non-4-yl)imidazo [2,1-b][1,3]thiazole-5-carboxamide monohydrate, (I).…”

“…The thiazole and imidazole rings are essentially coplanar, with a dihedral angle of 0.56 (7) . The mean C-S bond length [1.783 (2) Å ] may be compared with the corresponding values in similar molecules [1.7588 (2) Å (Ö ztü rk Yıldırım et al, 2005) and 1.729 (2) Å (Akkurt et al, 2005)].…”