6-Shogaol inhibits the proliferation, apoptosis, and migration of rheumatoid arthritis fibroblast-like synoviocytes via the PI3K/AKT/NF-κB pathway

Li, Nan; Li, Xiaojuan; Deng, Lijuan; Yang, Hongqiang; Gong, Zhaohui; Wang, Qiang; Pan, Dongmei; Zeng, Shan; Chen, Jiaxu

doi:10.1016/j.phymed.2022.154562

Cited by 19 publications

(2 citation statements)

References 34 publications

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“…This antiarthritic effect has also been shown in 6-shogaol. This ginger component causes the apoptosis of FLSs and MH7A cells and reduces their migration, invasion, and proliferation [ 76 ]. Additionally, 6-shogaol decreases the synthesis of MMP-2, MMP-9, IL-1β, IL-6, IL-8, and TNF-α, which are overexpressed in synovial tissues.…”

Section: In Vitro Preclinical Studiesmentioning

confidence: 99%

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Zingiber Officinale Roscoe: The Antiarthritic Potential of a Popular Spice—Preclinical and Clinical Evidence

Szymczak,

Grygiel-Górniak,

Cielecka-Piontek

2024

Nutrients

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The health benefits of ginger rhizomes (Zingiber officinale Roscoe) have been known for centuries. Recently, ginger root has gained more attention due to its anti-inflammatory and analgesic activities. Many of the bioactive components of ginger may have therapeutic benefits in treating inflammatory arthritis. Their properties seem especially helpful in treating diseases linked to persistent inflammation and pain, symptoms present in the course of the most prevalent rheumatic diseases, such as osteoarthritis (OA) and rheumatoid arthritis (RA). This review analyzes the current knowledge regarding ginger’s beneficial anti-inflammatory effect in both in vitro and in vivo studies as well as clinical trials. The drug delivery systems to improve ginger’s bioavailability and medicinal properties are discussed. Understanding ginger’s beneficial aspects may initiate further studies on improving its bioavailability and therapeutic efficacy and achieving more a comprehensive application in medicine.

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Section: In Vitro Preclinical Studiesmentioning

confidence: 99%

“…Similarly to in vitro studies, 6-shogaol has revealed antiarthritic properties in vivo [ 76 ]. Intraperitoneal injection of 6-shogaol (30 mg/kg/day or 60 mg/kg/day) for 21 consecutive days has been shown to reduce joint swelling in mice with collagen-induced arthritis (CIA).…”

Section: In Vivo Preclinical Studiesmentioning

confidence: 99%