600 Sevoflurane occupational exposure monitoring: A role of urinary hexafluoroisopropanolol

Simultaneous determination of unmodified sevoflurane and of its metabolite hexafluoroisopropanol in urine by headspace sorptive extraction–thermal desorption–capillary gas chromatography–mass spectrometry

“…This method provided good correlations with personal monitoring measurements of inhaled ppm concentrations [4]. HFIP has also recently been proposed as an exposure biomarker for operating room personnel [5,6]. However, quantification of HFIP in urine is difficult due to the need for a pre-analytical deconjugation step using acid hydrolysis or ␤-glucuronidase.…”