615 How Useful Is Acoustic Radiation Force Impulse Elastography (Arfi) to Predict the Presence of Significant Esophageal Varices in Cirrhotic Patients?

Bota, Simona; Sporea, Ioan; Şirli, Roxana; Focşa, Mircea; Popescu, Alina; Străin, Mihnea; Dănilă, Mirela

doi:10.1016/s0168-8278(12)60628-x

Cited by 5 publications

(8 citation statements)

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“…The use of ultrasound based elastography is becoming important in the non-invasive assessment of different organs: liver fibrosis [1,2], spleen stiffness, for predicting portal hypertension [3,4], thyroid nodules [5,6], prostate [7], focal liver lesions [8], or chronic kidney disease [9].…”

Section: Introductionmentioning

confidence: 99%

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Bob¹,

Grosu²,

Sporea³

et al. 2018

Med Ultrason

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Aim: To analyze the relationship between shear wave velocity in the kidney measured by point shear wave elastography using Virtual Touch Quantification (VTQ) (Siemens Acuson S2000) and histological parameters obtained from renal biopsies, in patients with chronic glomerulonephritis (CGN).Material and methods: The study group included 20 patients (mean age 47.95±13.59 years) with different types of CGN, that had underwent renal biopsy and 57 normal controls (mean age 38.07±17.32 years). In all patients, five valid stiffness measurements were obtained in each kidney, with the patient in lateral decubitus. Regarding the histological results, we assessed the presence or absence of glomerulosclerosis, interstitial fibrosis, and arteriolo-hyalinosis.Results: In patients with CGN we obtained the following mean values of VTQ values: right kidney: 2.12±0.81 m/s, left kidney 1.65±0.54 m/s, while in the normal controls significantly higher VTQ values were obtained: right kidney 2.69±0.72 m/s (p=0.004), left kidney 2.48±0.73 m/s (p<0.0001). In patients with CGN no statistically significant correlations between VTQ values and eGFR (r=0.37, p=0.12) or proteinuria (r=0.2, p=0.37) were found. We found significantly lower VTQ values in patients with interstitial fibrosis (1.46 vs. 1.99 m/s, p<0.05) and also in patients with arteriolo-hyalinosis (1.55 vs. 2.47 m/s, p<0.05).Conclusion: Our pilot study shows that shear wave velocity values in patients with CGN are significantly lower compared to normal controls, and there is a tendency to decrease with the decrease of eGFR, with the presence of interstitial fibrosis and of arteriolo-hyalinosis.

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Section: Introductionmentioning

confidence: 99%

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Bob¹,

Grosu²,

Sporea³

et al. 2018

Med Ultrason

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“…The separate use of LS or spleen stiffness (SS) has limited value for predicting the presence of significant EV (at least grade 2) in Romanian patients with liver cir-rhosis, with AUROC curves of approximately 0.60 [95]. These results are in line with European studies [96], and different from Asian studies [97,98], which showed that especially spleen stiffness can be useful for predicting the presence of EV.…”

Section: The Usefulness Of Arfi Elastography For Predicting the Complmentioning

confidence: 52%

“…For a cut-off value > 0.395, the accuracy of ARFI elastography for predicting the presence of significant EV can be increased to 70%, but not enough to replace upper gastrointestinal endoscopy in daily clinical practice [95].…”

Section: The Usefulness Of Arfi Elastography For Predicting the Complmentioning

confidence: 99%

Romanian national guidelines and practical recommendations on liver elastography

et al. 2014

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The use of liver elastography has substantially developed in the past few years; the introduction of novel elastographic methods (Transient Elastography, point Shear Wave Elastography, Real Time Shear Wave Elastography, Strain Elastography) has changed the perspective in the evaluation of liver disease. The ongoing research in this area is mainly focused on diffuse liver diseases and for predicting liver cirrhosis complication. This guideline created under the auspice of Romanian Society of Ultrasound in Medicine and Biology is intended to accustomize the clinician with the current practical use of liver elastography and has been issued to help in maximizing the clinical benefit for the patients with chronic liver diseases.

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“…In the study by Takuma et al [35], SSM was performed in 340 patients with liver cirrhosis, resulting in exceptionally high NPV (98.4% at cut-off value 3.18 m/s) for the presence of any grade of oesophageal varices or large oesophageal varices (NPV 99.4% at cut-off value of 3.30 m/s). In comparison, when Bota et al carried out SSM using ARFI technology, they obtained a very good predictive value for cirrhosis (AUROC 0.91), but were not able to distinguish patients with or without oesophageal varices, as well as differences between the grades of oesophageal varices [36].The same author created a formula for the prediction of significant oesophageal varices (at least grade 2) using an original formula with LSM, SSM and the presence of ascites, with reported accuracy of 69.6% and AUROC 0.721 [37].…”

Section: Pointswe (Pswe) In Portal Hypertensionmentioning

confidence: 99%

Non-invasive diagnosis of portal hypertension in cirrhosis using ultrasound based elastography

et al. 2017

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Liver stiffness measurement (LSM) by ultrasound-based elastography may be used to non-invasively discriminate between the stages of liver fibrosis, rule out cirrhosis and follow its evolution, including the prediction of the presence of oesophageal varices. The same is possible in order to diagnose clinically significant portal hypertension, referring primarilyto transient elastography and LSM values ≥20-25 kPa. The same approach may be used to reliably rule out the presence ofoesophageal varices (LSM <20 kPa + platelets >150x109/L). These recommendations refer primarily to patients with viral aetiology of chronic liver disease (hepatitis C), while additional studies are required for other aetiologies. While spleen stiffness measurement (SSM) also poses a logical choice in this indication, controversial results have nevertheless been published on this issue. It should be emphasized, however, that more recent data indicate that this parameter should be included in the diagnostic algorithm for portal hypertension, if not as the sole then as a part of a sequential algorithm, combined with LSM. Until now, transient elastography has been most extensively studied and founded on scientific evidence, although the results of other ultrasound-based elastography techniques demonstrate the same trend for the non-invasive assessment of portal hypertension.

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615 How Useful Is Acoustic Radiation Force Impulse Elastography (Arfi) to Predict the Presence of Significant Esophageal Varices in Cirrhotic Patients?

Cited by 5 publications

References 0 publications

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Is there a correlation between kidney shear wave velocity measured with VTQ and histological parameters in patients with chronic glomerulonephritis? A pilot study

Romanian national guidelines and practical recommendations on liver elastography

Non-invasive diagnosis of portal hypertension in cirrhosis using ultrasound based elastography

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