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Al-Mizyen, E.; Sabatini, Luca; Lower, A.M.; Wilson, Claire; Al-Shawaf, Talha; Grudzinskas, J.G.

doi:10.1023/a:1009462004650

Cited by 22 publications

(2 citation statements)

References 39 publications

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“…Even though there are no differences noted in the pregnancy rates, pretreatment with OCP may increase the duration of stimulation. [ 71 72 ]…”

Section: Managementmentioning

confidence: 99%

Poor ovarian reserve

Jirge¹

2016

J Hum Reprod Sci

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Poor ovarian reserve (POR) is an important limiting factor for the success of any treatment modality for infertility. It indicates a reduction in quantity and quality of oocytes in women of reproductive age group. It may be age related as seen in advanced years of reproductive life or may occur in young women due to diverse etiological factors. Evaluating ovarian reserve and individualizing the therapeutic strategies are very important for optimizing the success rate. Majority or women with POR need to undergo in vitro fertilization to achieve pregnancy. However, pregnancy rate remains low despite a plethora of interventions and is associated with high pregnancy loss. Early detection and active management are essential to minimize the need for egg donation in these women.

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“…Even though there are no differences noted in the pregnancy rates, pretreatment with OCP may increase the duration of stimulation. [ 71 72 ]…”

Section: Managementmentioning

confidence: 99%

Poor ovarian reserve

Jirge¹

2016

J Hum Reprod Sci

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“…In contrast, no significantly better outcome following preintervention with OCs was observed in another clinical trial ( 29 ). Recently, OCs, combined with GnRH agonists or antagonists, have been used in IVF programs to prevent a premature LH peak ( 30 – 32 ) and improve reproductive outcomes in PCOS patients ( 33 , 34 ). However, growing concerns have been raised regarding the potential detrimental efficiency of OCs usage on reproductive outcomes for patients undergoing infertility treatment ( 35 – 38 ).…”

Section: Discussionmentioning

confidence: 99%

Role of luteinizing hormone elevation in outcomes of ovulation induction with letrozole for polycystic ovary syndrome

Kuang

2023

Front. Med.

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IntroductionThe effect of elevated luteinizing hormone (LH) on the clinical outcomes of ovulation induction (OI) in infertile anovulatory patients with polycystic ovary syndrome (PCOS) remains controversial. This retrospective study included PCOS patients undergoing intrauterine insemination (IUI) following letrozole (LE) stimulation without OC pretreatment.Materials and methodsA retrospective cohort analysis was conducted in a single, academic ART center from January 2013 to May 2019. In total, 835 IUI cycles of PCOS patients treated with letrozole were collected for the analysis. Cohorts were separated based on the level of basal LH (bLH) and LH level after letrozole administration (LHle) during OI. OI response and reproductive outcomes were evaluated for each cohort.ResultsNo adverse effects of dysregulated levels of either bLH or LHle on ovulation rate or reproductive outcomes were observed. Furthermore, the cohort of individuals with normal bLH and high LHle levels, exclusive of LH surge, exhibited significantly higher rates of clinical pregnancy (30.3% vs. 17.3%, p = 0.002) and live birth (24.2% vs. 15.2%, p = 0.024) than those with normal bLH and normal LHle.ConclusionThese results indicated that high LH levels in PCOS are not solid evidence of poor prognosis of letrozole-induced ovulation, while elevated LHle may be a prospective predictor for better OI outcomes. It seems that preinhibition of LH secretion is not needed.

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Oral contraceptive pill, progestogen or estrogen pre-treatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques

Smulders

Oirschot

Farquhar

et al. 2010

Cochrane Database of Systematic Reviews

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Background For many subfertile women, assisted reproductive techniques (ART) is the only hope for a pregnancy and live birth. The combined oral contraceptive pill (OCP) given prior to the hormone therapy in an IVF cycle may result in better pregnancy outcomes of ART. Objectives To assess whether pre-treatment with combined OCPs, progestogens or estrogens in ovarian stimulation protocols affects outcomes in subfertile couples undergoing ART. Search methods We searched the Cochrane Menstrual Disorders and Subfertility Group Specialised Register, The Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, PsycINFO. Other electronic resources on the Internet, reference list of relevant articles were also searched as well as the ESHRE abstracts (2008). All these searches were conducted in November 2008. Selection criteria Randomised controlled trials of pre-treatment with combined OCP, progestogen or estrogen in subfertile women undergoing IVF/ ICSI. Data collection and analysis Two authors independently extracted the data and assessed risk of bias. We calculated Peto odds ratios for dichotomous data and weighted mean difference for continuous variables. Authors of trials were contacted in case of missing data. 1 Oral contraceptive pill, progestogen or estrogen pre-treatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques (Review)

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Abstract: We conclude that pre-IVF treatment with oral contraceptive pill or gestogen combined with the flare protocol in women at high risk of or with a history of poor ovarian response, as defined in this study, did not appear to result in an improvement in outcome of IVF-embryo transfer.

Cited by 22 publications

References 39 publications

Poor ovarian reserve

Poor ovarian reserve

Role of luteinizing hormone elevation in outcomes of ovulation induction with letrozole for polycystic ovary syndrome

Oral contraceptive pill, progestogen or estrogen pre-treatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques

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