622: Index Case of Community-Acquired MDR Pseudomonas Aeruginosa Meningitis

Salick, Muhammad; Al-Faris, Faris; Wazir, Ali; Dsouza, Melissa; Beegle, Scott

doi:10.1097/01.ccm.0000551374.77511.e8

Cited by 1 publication

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“…In addition, Multidrug Resistant (MDR) strains were identified in patients with neurosurgical interventions and patient with nosocomial exposure. This study is providing one of the fatal cases regarding community-acquired MDR pseudomonal meningitis [48]. One of the uncommon causes of ventriculitis and meningitis is P. aeruginosa, yet is commonly related to considerable mortality and morbidity [49].…”

Section: P Aeruginosa Associated Meningitismentioning

confidence: 99%

Pseudomonas aeruginosa: Diseases, Biofilm and Antibiotic Resistance

Al-Dahmoshi¹,

Al-Obaidi²,

Al-Khafaji³

2021

Pseudomonas Aeruginosa - Biofilm Formation, Infections and Treatments

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Pseudomonas aeruginosa is Gram negative bacteria that can adapt to extreme environmental conditions and withstand to different antibacterial agents. It si responsible for arrays of infections both community and hospital acquired especially ICU infections. Respiratory tract infection, blood stream infection, wound infection, burn infection, and urinary tract infections ware top five P. aeruginosa infections. Additionally as an opportunistic bacteria, it may be associated with healthcare infections in intensive care units (ICUs), ventilator-associated pneumonia (VAP), central line-associated blood stream infections, surgical site infections, otitis media, and keratitis. P. aeruginosa can form biofilms as self-produced extracellular matrix to protects the cells from antibiotics and the host immune response. Antibiotic resistance was an prominent feature of this pathogen and can donate it one of the three resistance patterns: Multidrug (MDR), extensive drug (XDR) and pan drug resistance. It exploit many resistance mechanisms ranged from overexpression of drug efflux systems protein, modifying enzyme production, reducing the permeability and using shelters like biofilms.

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Section: P Aeruginosa Associated Meningitismentioning

confidence: 99%