63. Association of Hormonal Contraception Initiation With Subsequent Depression Diagnosis And Antidepressant Use In United States Military Health System Beneficiaries: A Cohort Study

Ditch, Sarah; Hansen, Shana; Roberts, Timothy T.

doi:10.1016/j.jadohealth.2018.10.078

Cited by 2 publications

(1 citation statement)

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“…(Fig. 5) Use of antidepressants was reported in 3 studies [31][32][33] with a total sample size of over one million and the number of events reported as around 30,000 incidents in women without previous mental disorders or general women. When all hormonal contraceptives (HC) were compared with no contraceptive use, the overall effect size was 45% higher among users compared to non-users (1.45, 95% CI 1.41, 1.49).…”

Section: Depressionmentioning

confidence: 99%

Assessing the impact of contraceptive use on mental health among women of reproductive age – a systematic review

Jahanfar,

Mortazavi,

Lapidow

et al. 2024

BMC Pregnancy Childbirth

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Background Contraceptive use is the principal method by which women avoid unintended pregnancy. An unintended pregnancy can induce long-term distress related to the medical, emotional, and social consequences of carrying that pregnancy to term. Objectives This review investigates the effects of modern contraception techniques such as birth control pills, long-acting reversible contraceptives (e.g., intrauterine devices, implants), and condoms on mental health status. Methods We searched multiple databases from inception until February 2022, with no geographical boundaries. RCTs underwent a quality assessment using the GRADE approach while the quality of observational studies was assessed using the Downs and Black scoring system. Data were analyzed through meta-analysis and relative risk and mean difference were calculated and forest plots were created for each outcome when two or more data points were eligible for analysis. Main results The total number of included studies was 43. In women without previous mental disorders, both RCTs (3 studies, SMD 0.18, 95% CI [0.02, 0.34], high quality of evidence) and cohort studies (RR 1.04 95% CI [1.03, 1.04]) detected a slight increase in the risk of depression development. In women with previous mental disorders, both RCTs (9 studies, SMD − 0.15, 95% CI [-0.30, -0.00], high quality of evidence) and cohort studies (SMD − 0.26, 95% CI [-0.37, -0.15]) detected slight protective effects of depression development. It was also noticed that HC demonstrated protective effects for anxiety in both groups (SMD − 0.20, 95% CI [-0.40, -0.01]). Conclusions Among women with pre-existing mental disorders who use hormonal contraceptives, we reported protective association with decreased depressive symptoms. However, the study also draws attention to some potential negative effects, including an increase in the risk of depression and antidepressant use among contraceptive users, a risk that is higher among women who use the hormonal IUD, implant, or patch/ring methods. Providers should select contraceptive methods taking individual aspects into account to maximize benefits and minimize risks.

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Section: Depressionmentioning

confidence: 99%

Assessing the impact of contraceptive use on mental health among women of reproductive age – a systematic review

Jahanfar,

Mortazavi,

Lapidow

et al. 2024

BMC Pregnancy Childbirth

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Women's health, hormonal balance, and personal autonomy

2023

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Hormone-based contraception disrupts hormonal balance, creating artificial states of anovulation and threatening women's health. We reviewed its main adverse effects and mechanisms on accelerated ovarian aging, mental health (emotional disruptions, depression, and suicide), sexuality (reduced libido), cardiovascular (brain stroke, myocardial infarction, hypertension, and thrombosis), and oncological (breast, cervical, and endometrial cancers). Other “collateral damage” includes negative effects on communication, scientific mistrust, poor physician–patient relationships, increased patient burden, economic drain on the healthcare system, and environmental pollution. Hormone-sensitive tumors present a dilemma owing to their potential dual effects: preventing some cancers vs. higher risk for others remains controversial, with denial or dismissal as non-relevant adverse effects, information avoidance, and modification of scientific criteria. This lack of clinical assessment poses challenges to women's health and their right to autonomy. Overcoming these challenges requires an anthropological integration of sexuality, as the focus on genital bodily union alone fails to encompass the intimate relational expression of individuals, complete sexual satisfaction, and the intertwined feelings of trust, safety, tenderness, and endorsement of women's femininity.

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63. Association of Hormonal Contraception Initiation With Subsequent Depression Diagnosis And Antidepressant Use In United States Military Health System Beneficiaries: A Cohort Study

Cited by 2 publications

References 0 publications

Assessing the impact of contraceptive use on mental health among women of reproductive age – a systematic review

Assessing the impact of contraceptive use on mental health among women of reproductive age – a systematic review

Women's health, hormonal balance, and personal autonomy

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