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doi:10.13040/ijpsr.0975-8232.7(5).1915-27

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…They contain 4099 different biological activities and were used for a theoretical evaluation of the anticancarcinogenic properties of the flavanones in the study. PASS Online permits the determination of the activity specter of the compounds in terms of probable activity ( Pa ) on a scale of results from 0 to 1 [ 24 , 25 ]. To use the web platforms, it must be assured that the scheme correctly draws the chemical structures, taking into consideration the spatial set out of each substitute and function present and considering the configuration of the stereogenic ( R ) and ( S ).…”

Section: Methodsmentioning

confidence: 99%

In Vitro Approaches to Explore the Anticancer Potential of One Natural Flavanone and Four Derivatives Loaded in Biopolymeric Nanoparticles for Application in Topical Delivery Treatments

et al. 2023

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The increasing number of skin cancer cases worldwide and the adverse side effects of current treatments have led to the search for new anticancer agents. In this present work, the anticancer potential of the natural flavanone 1, extracted from Eysenhardtia platycarpa, and four flavanone derivatives 1a–d obtained by different reactions from 1 was investigated by an in silico study and through cytotoxicity assays in melanoma (M21), cervical cancer (HeLa) cell lines and in a non-tumor cell line (HEK-293). The free compounds and compounds loaded in biopolymeric nanoparticles (PLGA NPs 1, 1a–d) were assayed. A structure–activity study (SAR) was performed to establish the main physicochemical characteristics that most contribute to cytotoxicity. Finally, ex vivo permeation studies were performed to assess the suitability of the flavanones for topical administration. Results revealed that most of the studied flavanones and their respective PLGA NPs inhibited cell growth depending on the concentration; 1b should be highlighted. The descriptors of the energetic factor were those that played a more important role in cellular activity. PLGA NPs demonstrated their ability to penetrate (Qp of 17.84−118.29 µg) and be retained (Qr of 0.01−1.44 g/gskin/cm2) in the skin and to exert their action for longer. The results of the study suggest that flavanones could offer many opportunities as a future anticancer topical adjuvant treatment.

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Section: Methodsmentioning

confidence: 99%

In Vitro Approaches to Explore the Anticancer Potential of One Natural Flavanone and Four Derivatives Loaded in Biopolymeric Nanoparticles for Application in Topical Delivery Treatments

et al. 2023

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“…Molinspiration ® server (http://www. molinspiration.com accessed on 18 February 2021) and PASS Online (Prediction of Activity Spectra for substance, http://way2drug.com/PassOnline accessed on 18 February 2021) were used to predict the bioactivity [26,59] of the flavanones 1, 1a-d.…”

Section: In Silico Analysismentioning

confidence: 99%

Screening Anti-Inflammatory Effects of Flavanones Solutions

Bustos-Salgado

Andrade-Carrera

Domínguez-Villegas

et al. 2021

IJMS

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There are a large number of remedies in traditional medicine focused on relieving pain and inflammation. Flavanones have been a potential source in the search for leading compounds and biologically active components, and they have been the focus of much research and development in recent years. Eysenhardtia platycarpa is used in traditional medicine for the treatment of kidney diseases, bladder infections, and diabetes mellitus. Many compounds have been isolated from this plant, such as flavones, flavanones, phenolic compounds, triterpenoid acids, chalcones, sugars, and fatty acids, among others. In this paper, natural flavanone 1 (extracted from Eysenhardtia platycarpa) as lead compound and flavanones 1a–1d as its structural analogues were screened for anti-inflammatory activity using Molinspiration® and PASS Online in a computational study. The hydro alcoholic solutions (FS) of flavanones 1, 1a–1d (FS1, FS1a–FS1d) were also assayed to investigate their in vivo anti-inflammatory cutaneous effect using two experimental models, a rat ear edema induced by arachidonic acid (AA) and a mouse ear edema induced by 12-O-tetradecanoylphorbol acetate (TPA). Histological studies and analysis of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 were also assessed in AA-inflamed rat ear tissue. The results showed that the flavanone hydro alcoholic solutions (FS) caused edema inhibition in both evaluated models. This study suggests that the evaluated flavanones will be effective when used in the future in skin pathologies with inflammation, with the results showing 1b and 1d to be the best.

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Abstract: ABSTRACT:Six new Phthalic acid amides of the general formula C8H5O3-NH-R

Cited by 2 publications

References 5 publications

In Vitro Approaches to Explore the Anticancer Potential of One Natural Flavanone and Four Derivatives Loaded in Biopolymeric Nanoparticles for Application in Topical Delivery Treatments

In Vitro Approaches to Explore the Anticancer Potential of One Natural Flavanone and Four Derivatives Loaded in Biopolymeric Nanoparticles for Application in Topical Delivery Treatments

Screening Anti-Inflammatory Effects of Flavanones Solutions

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