64-Slice computed tomography angiography in the diagnosis and assessment of coronary artery disease: systematic review and meta-analysis

Mowatt, G; Cook, Jonathan; Hillis, Graham S.; Walker, Shonagh Mary; Fraser, Cynthia; Jia, Xueli; Waugh, Norman

doi:10.1136/hrt.2008.145292

Cited by 444 publications

(235 citation statements)

References 40 publications

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“…With the advent of technology, the performance of this modality has further improved, providing near 100% sensitivity and >90% specificity as well as further reducing radiation dosage to approximately 10% that of IA (9)(10)(11)(12). Moreover, a CTCA study can be completed within minutes and along with its non-invasive characters may enable optimal CAD detection with decreased health care costs and fewer complications (13).…”

Section: Introductionmentioning

confidence: 99%

Computed Tomography Coronary Angiography as Initial Work-Up for Unstable Angina Pectoris

Koulaouzidis

Powell²,

McArthur³

et al. 2012

ELECTRON J GEN MED

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Section: Introductionmentioning

confidence: 99%

Computed Tomography Coronary Angiography as Initial Work-Up for Unstable Angina Pectoris

Koulaouzidis

Powell²,

McArthur³

et al. 2012

ELECTRON J GEN MED

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“…Coronary artery calcifications are highly frequent and extensive disease in MHP population [8][9][10][11]. Detection of such calcifications may be helpful in clinical practice [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Coronary Artery Calcification in Chronic Dialysis Patients

Asserraji¹

2014

Angiol

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Coronary artery calcifications (CAC) are highly prevalent in asymptomatic maintenance dialysis patients (MHP), detection and surveillance of such coronary disease could be helpful in clinical practice. In cross-sectional study conducted in our dialysis Unit, including 49 MHP, We have assessed and quantified coronary artery calcification and theirs risk factors. Detection and quantification of coronary calcifications were made by Multi Slice Cardio Tomography (MSCT) a high-speed scanner 64 row. The total volume and the density of calcifications were assessed in six coronary arteries with determination of calcium coronary Agatston score (CCAS). Patients were classified into 2 groups: (1) No or Moderate calcification with CCAS= 0-400; and (1) Severe calcification with CCAS >400. Demographic and biological data were analyzed. Forty nine patients were enrolled in the study (26 men and 23 women), median age was 57 (49-65.00) years, the mean duration of dialysis was 80.43 (57. 00-65.00) months. Diabetes mellitus was the most frequent etiology of end stage renal disease (40.8%). The median CCAS was 22, 00 (00-201.5). 38 patients (77.6 %) showed no or moderate coronary calcification (CCAS=0-400) and severe calcification (CCAS >400) were found in 11 patients (22.4 %). Positive correlation exists between Severe calcification with (CCAS >400) and conventional cardiovascular risk factors such age (p=0, 02), male gender (p=0.05), diabetes (p=0.03) and calcémia (0.03). The AIVA was the first site of calcification (69.4%) followed by the RCA (36.7%) and the Cx A (30.6%). Calcifications were present simultaneously in two coronary arteries in 66% of cases. The number of calcified arteries increased with age (r=0.396, p=0.005). Multi Slice Cardio Tomography (MSCT) seems to be an effective, non-invasive and reusable method to assess and quantify coronary artery calcification and their progression.

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“…A good quality negative CCTA without artifacts can rule out the presence of CAD with a great level of confidence. The high negative predictive value has been consistently demonstrated (Gopalakrishnan et al 2008;Mowatt et al 2008;Stein et al 2008) and it is this population where coronary CTA might well be a substitute for invasive angiography. Figure 1 demonstrates a normal high quality coronary CT angiogram and figure 2 demonstrates one in which the diagnosis of high -grade coronary artery disease was made.…”

Section: Ccta As An Alternative To Invasive Angiographymentioning

confidence: 99%