640 Prevalence of Gestational Diabetes and Associated Maternal and Neonatal Complications in a Fast Developing Community: Global Comparisons

Abstract

Background:The prevalence of gestational diabetes (GDM) is increasing all over the world. Hence, the impact of GDM on maternal and infant health is an important topic of research. No study has been conducted in Qatar to evaluate the outcome of pregnancies complicated by diabetes mellitus. Objective: The aim of the study was to determine the prevalence of GDM, compare the maternal-neonatal complications among women with GDM and non-GDM pregnant women, and investigate the risk factors and potential outcomes associated with GDM. Design: This is a prospective cohort study. Setting: The survey was carried out at the antenatal clinics of the Women's Hospital, Qatar. Subjects and methods: A representative sample of 2056 pregnant women who attended the antenatal clinics of the Women's Hospital were surveyed during the period from the first week of January 2010 to April 2011. From this sample, 1608 women (78.2%) expressed their consent to participate in the study. Questionnaires were administered to pregnant women who were seeking antenatal care at this urban hospital. The questionnaire covered variables related to sociodemographic factors, family history, medical history, maternal complications, and neonatal outcome. Results:The prevalence of GDM in Qatar was 16.3%. Women with GDM were significantly higher in the age group of 35-45 years (45%; P = 0.001). Family history of diabetes (31.7%; P , 0.001), increased parity (55.3%; P = 0.004), and obesity (59.2%; P , 0.001) were determinants of GDM in pregnant women. Maternal complications like pregnancy-induced hypertension (19.1% vs 10.3%; P , 0.001), pre-eclampsia (7.3% vs 3.8%; P = 0.012), antepartum hemorrhage (19.2% vs 14.6%; P = 0.05), and cesarean (27.9% vs 12.4%; P , 0.001) were significantly higher in GDM women. Neonates were at increased risk of preterm birth (12.6% vs 8.3%; P = 0.03), macrosomia (10.3% vs 5.9%; P = 0.01), and birth trauma (8% vs 3%; P , 0.001). Conclusion:The study findings revealed that GDM was higher in women in Qatar and that they were at increased risk of developing maternal and neonatal complications. Obesity emerged as an essential risk factor for subsequent GDM. The advanced maternal age, low monthly income, family history of diabetes, and obesity were the main significant risk factors for GDM.

Gestational diabetes mellitus — literature review on selected cytokines and hormones of confirmed or possible role in its pathogenesis

“…Gestational diabetes mellitus (GDM) is a glucose intolerance disorder with onset or first recognition during pregnancy, which, however, does not meet the criteria of diabetes mellitus for the general population [1,2]. Based upon available publications, the prevalence of GDM varies widely -from 1% to 22% of pregnant women, depending on the examined group of patients and adopted GDM diagnostic criteria.…”

“…Based upon available publications, the prevalence of GDM varies widely -from 1% to 22% of pregnant women, depending on the examined group of patients and adopted GDM diagnostic criteria. Its frequency increases globally [1][2][3][4][5][6][7][8]. Screening for GDM is an obligatory element of managing pregnant woman in many countries, including Poland.…”