648What is the optimal dose of botulinum toxin a dysport in neurogenic detrusor overactivity? A dose-effect study

Botulinum toxin A in the overactive bladder: current status and future directions

“…Studies suggest that Botox has a duration of effect of ≥ 6 months. Across the four Dysport studies [10,22,33,38] there is more variation, suggesting greater inter‐patient variability and a shorter duration of effect in some cases (the range for the studies reported here being 1–12 months) although this could also simply reflect different doses. Additional research might help to establish when to re‐inject and what dose to use.…”

“…Four of these studies also included a separate IDO group. Except for a few studies that did not specify inclusion criteria [15,17,20,22,38], these studies included patients who were refractory to, or unable to tolerate, anticholinergic therapy. Most of the studies used Botox (16), while three used Dysport and five cited the use of both in the study population.…”

“…Twenty‐seven citations were found that documented the use of BTX‐A in patients with NDO, of which 14 studies were published in full (Table 1) [15,17–45]. These studies involved 1167 patients with NDO in total.…”

“…Twelve of the identified studies enrolled a mixed population of patients with different causes for their DO. All of these studies show less frequent or severe incontinence symptoms after BTX‐A treatment [15,21,25,27,28,30,34,35,38,41,44,45]. However, the data are not analysed according to the cause of NDO and therefore provide no information on whether some groups are more likely to benefit from BTX‐A treatment than others.…”

“…To date, there are few reports of the use of Dysport in adults [10,22,33,38], in addition to four combined Dysport/Botox studies [21,25,43,48]. Unfortunately, the administration protocols for these investigations are so varied that no conclusions can be drawn.…”